Results 161 to 170 of about 5,255,084 (312)

Damage-Accumulation-Induced Crack Propagation and Fatigue Life Analysis of a Porous LY12 Aluminum Alloy Plate. [PDF]

Materials (Basel), 2023
Lv C, Wang K, Zhao X, Wang F.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Facial Melanosis in Skin of Color: An Integrated Clinical, Dermoscopic, and Quality of Life Analysis. [PDF]

Cureus
Goswami A, Marak A, Verma S, Chingshubam B, Khan SRH.   +4 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Proceedings of the 7th Australian Conference on Quality of Life

, 2006
The refereed papers from this international conference held at Deakin University in November 2005 are now online. Papers include Robert Cummins on \u27The wellbeing of caregivers\u27, and Peter Kriel on \u27Quality of work life and business ethics\u27 ...

core  

Theory of Peaceful End of Life: Analysis and Evaluation Using the Whall Framework. [PDF]

Int J Health Plann Manage
Velasco Yanez RJ, Almeida De Lima AL, De Oliveira Lopes M, Martins Da Silva V, Carvalho Fernandes AF, Freitas MC.   +5 more
europepmc   +1 more source

Large-scale real-life analysis of survival and usage of therapies in multiple myeloma. [PDF]

J Hematol Oncol, 2023
Lopez-Muñoz N, Hernández-Ibarburu G, Alonso R, Sanchez-Pina JM, Ayala R, Calbacho M, Cuellar C, Cedena MT, Jiménez-Ubieto A, Iñiguez R, Pedrera M, Cruz J, Meloni L, Pérez-Rey D, Serrano P, de la Cruz J, Martinez-Lopez J, Martinez-Lopez J.   +17 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Life Cycle Analysis of Bulk-Handling Equipment (BHE): Identifying Key Strategies for Carbon Footprint Reduction [PDF]

openBulk handling equipments (BHE) are critical to industrial manufacturing processes, especially in the processing of large amount of bulk materials in the construction and mining industries.
DUKULY, JANNEH VENICIA
core  

Analysis of possible baseline and treatment-course factors associated with non-remission in patients with Crohn's disease treated with ustekinumab: a retrospective real-life analysis. [PDF]

Pharmacol Rep
Tursi A, Pellegrino R, Mocci G, Elisei W, Scaldaferri F, Savarino EV, Maconi G, Bodini G, Papa A, Gravina AG.   +9 more
europepmc   +1 more source