Results 71 to 80 of about 8,753,852 (289)
Redox BiologyConstitutive activation of the transcription factor NRF2 confers therapeutic resistance in glioblastoma (GBM), however, this hyperactivation frequently persists despite the presence of intact KEAP1, suggesting the existence of KEAP1-independent ...
Wanting Xu +5 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Advanced ScienceSmurf1 mediates lysosomal biogenesis upon endomembrane damage by interacting with lysosomal injury sensor Gal3 and phosphatase CaN to form Gal3‐CaN‐Smurf1 complex, which is critical for TFEB dephosphorylation.
Qin Xia +10 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Work/Life Balance - Learning Package
, 2011 This Learning Activity provides an introduction to the topic of work/life balance. It will establish the importance of a good work/life balance relationship in life.
EVOLUTION +4 more
core
The relationship between work and non-work support and work-life balance in Taiwan [PDF]
, 2009 The aim of this study is to explore the relationship between employees' supportive resource (workplace support and non-work support) and their work-life balance in Taiwan.
Chang, Ruby Yi-Ju
core
Work Life Balance of Female Doctors in Bangladesh: An Overview
, 2019 The role women carry out today is somewhat different compared to earlier times due to the necessity of balancing the work of their home and job simultaneously.
Fabia Hannan Mone +3 more
core +1 more source
Bringing Work-Life Balance to Extension
Journal of Human Sciences and Extension, 2018 Throughout its one hundred plus years of history, the Cooperative Extension System has experienced many changes. Since its beginning, the Extension System has revolutionized nonformal educational approaches and outreach methods.
Dhruti Patel
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source