Results 121 to 130 of about 3,899,122 (312)

Association of sociodemographic characteristics, cardiovascular symptoms and psychosocial stressors in elderly depressed patients with coronary artery disease [PDF]

Einstein (São Paulo), 2006
Objective: To describe the prevalence of depressive symptoms inelderly patients with coronary artery disease and to compare theclinical and socio-demographic characteristics between depressedand non-depressed patients.
Miriam Ximenes Pinho, Osvladir Custodio, Marcia Makdisse, Manes Erlichman, Jose Antonio Gordillo, Vera Laet, Maria José Carvalho, Antônio Carlos Carvalho   +7 more
doaj  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A novel application of lemmatize and thematic analysis to understand protective measures perspectives of patients with chronic respiratory disease during the first outbreak of COVID-19 pandemic: a qualitative study

Frontiers in Public Health
ObjectiveTo describe the perspectives of a group of COPD patients during the first outbreak of the COVID-19 pandemic and narrate the emotions and polarity (acceptance-rejection) regarding living with COPD during the pandemic.Design/methodsWe used a novel
Domingo Palacios-Ceña, David Peña-Otero, David Peña-Otero, Ciro Casanova-Macario, Juan Nicolas Cuenca-Zaldivar, Juan Nicolas Cuenca-Zaldivar, Cristina Garcia-Bravo, Cesar Fernandez-de-las-Peñas, David Díaz-Pérez   +8 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Estimating the Undercoverage of a Sampling Frame due to Reporting Delays

, 2003
One of the imperfections of a sampling frame is miscoverage caused by delays in recording real- life events that change the eligibility of population units. For example, new units generally appear on the frame some time after they came into existence and
Fenton, Trevor, Hedlin, Dan, MacDonald, John W., Pont, Mark, Wang, Suojin   +4 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Evolutions of personal networks and life events

, 2005
http://www.sciencedirect.com/science/journal/03788733International audienceNetworks of personal relations evolve over time. They reflect and go with processes of socialization. Their history and dynamics contribute to their present structure.
Bidart, Claire, Lavenu, Daniel
core  

Reducing Global Warming and Adapting to Climate Change: The Potential of Organic Agriculture [PDF]

, 2012
Climate change mitigation is urgent and adaptation to climate change is crucial, particularly in agriculture, where food security is at stake. Agriculture, currently responsible for 20-30% of global greenhouse gas emissions counting direct and indirect ...
Davis, J., Dyrtrtová, K., Gattinger, A., Lampkin, N., Muller, Adrian, Niggli, U., Olesen, J., Smith, L.   +7 more
core