Results 51 to 60 of about 1,486,978 (306)

Demolish or Rebuild? Life Cycle Cost Analysis and Maintenance Plan for the Pro-Get-One Case Study

open access: yesTema, 2022
It is well known that a large part of the existing Italian and European building stock needs to improve its seismic and energy performances through deep renovation projects.
Marco Alvise Bragadin   +2 more
doaj   +1 more source

Modelling User-Costs in Life Cycle Cost-Benefit (LCCB) analysis [PDF]

open access: yes, 2008
The importance of including user’s costs in Life-Cycle Cost-Benefit analysis of structures is discussed in this paper. This is especially for bridges of great importance.
Thoft-Christensen, Palle
core   +2 more sources

Level(s) – A common EU framework of core sustainability indicators for office and residential buildings: Part 3: How to make performance assessments using Level(s) (Beta v1.0) [PDF]

open access: yes, 2017
Developed as a common EU framework of core indicators for the sustainability of office and residential buildings, Level(s) provides a set of indicators and common metrics for measuring the performance of buildings along their life cycle.
CORDELLA MAURO   +3 more
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Life Cycle Cost Analysis and Deterioration Patterns of Limestone Paving

open access: yesApplied Sciences
Stone is a durable and high-performance paving material in standard and in intensive service regimes. Stone is thus a preferable material for sidewalk and promenade paving under intensive service regimes, such as touristic promenades and historic sites ...
Irena (Rina) Wasserman, Igal M. Shohet
doaj   +1 more source

Effects of safety barrier life cycle cost factors - identification and analysis

open access: yesMATEC Web of Conferences, 2018
The costs borne by road infrastructure authorities for managing and maintaining road devices such as safety barriers may be very high. This has prompted the need for identifying and analysing in detail all factors that influence the costs of safety ...
Kristowski Adam   +3 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Evaluation of the economic and environmental performance of low-temperature heat to power conversion using a reverse electrodialysis - Multi-effect distillation system [PDF]

open access: yes, 2019
In the examined heat engine, reverse electrodialysis (RED) is used to generate electricity from the salinity difference between two artificial solutions.
Cipollina A.   +6 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

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