Results 101 to 110 of about 427,526 (314)

Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages. [PDF]

Antimicrob Agents Chemother, 2022
Sake SM, Kosch C, Blockus S, Haid S, Gunesch AP, Zhang X, Friesland M, Trummer SB, Grethe C, Kühnel A, Rückert J, Duprex WP, Huang J, Rameix-Welti MA, Empting M, Fischer N, Hirsch AKH, Schulz TF, Pietschmann T.   +18 more
europepmc   +1 more source

Cost Projections for the Product Life Cycle at the Early Stages of Product Development

, 2021
Marcin Relich, Grzegorz Bocewicz, Zbigniew Banaszak   +2 more
openalex   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Coupling between Ribotypic and Phenotypic Traits of Protists across Life Cycle Stages and Temperatures. [PDF]

Microbiol Spectr, 2021
Zou S, Fu R, Deng H, Zhang Q, Gentekaki E, Gong J.   +5 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut Bacterial Diversity in Different Life Cycle Stages of Adelphocoris suturalis (Hemiptera: Miridae). [PDF]

Front Microbiol, 2021
Xue H, Zhu X, Wang L, Zhang K, Li D, Ji J, Niu L, Wu C, Gao X, Luo J, Cui J.   +10 more
europepmc   +1 more source

The Epidermal Growth Factor Receptor Is a Relevant Host Factor in the Early Stages of The Zika Virus Life CycleIn Vitro

, 2021
Catarina Sabino, Daniela Bender, Marie‐Luise Herrlein, Eberhard Hildt   +3 more
openalex   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Dual RNA Sequencing Reveals Key Events When Different Giardia Life Cycle Stages Interact With Human Intestinal Epithelial Cells In Vitro. [PDF]

Front Cell Infect Microbiol, 2022
Rojas L, Grüttner J, Ma'ayeh S, Xu F, Svärd SG.   +4 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source