Life cycle stages of <i>Hepatozoon ingwe</i> (Apicomplexa: Adeleorina: Hepatozoidae) in an <i>Ixodes</i> sp. tick vector (Arthropoda: Ixodida: Ixodidae) and an African leopard <i>Panthera pardus pardus</i>. [PDF]
van As M +4 more
europepmc +1 more source
Different Life Cycle Stages of Plasmodium falciparum Induce Contrasting Responses in Dendritic Cells. [PDF]
Yap XZ +5 more
europepmc +1 more source
The immune system utilizes two distinct effector mechanisms of T cells depending on two different life cycle stages of a single pathogen, Toxoplasma gondii, to control its cerebral infection. [PDF]
Suzuki Y.
europepmc +1 more source
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Gene expression profiles of dicyemid life-cycle stages may explain how dispersing larvae locate new hosts. [PDF]
Lu TM, Furuya H, Satoh N.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Editosome RNase III domain interactions are essential for editing and differ between life cycle stages in Trypanosoma brucei. [PDF]
McDermott SM, Carnes J, Stuart K.
europepmc +1 more source

