Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The study of the correspondence of marketing instruments to the stages of the start-up life cycle
The article is devoted to the results of an empirical study of the correspondence of market research methods and promotion tools to the stages of the life cycle of start-ups on the Russian market.
Nikiforova Svetlana
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
A stage characteristic—Preserving product life cycle modeling
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Chang, Ping-Teng, Chang, Ching-Hsiang
openaire +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
REBRANDING AS A PATTERN OF THE PRODUCT BRAND PROMOTION
The organizations face to a lack of information for the development and adoption of effective management decisions in modern competitive circumstances.
Эрнст Раисович Сафаргалиев +1 more
doaj
Organisational life cycle, business orientation and performances of architectural firms in Nigeria
This study sets out to investigate the relationships between the organisational life cycles, business orientation and performances of architectural firms, which often start with just the principal and little capital. In the study, the organisational life
Adedapo Adewunmi Oluwatayo +2 more
doaj +1 more source
Do Life-Cycles Affect Financial Reporting Quality? Evidence from Emerging Market
This paper aims to present the effect of life cycle on financial reporting quality (FRQ). Discretionary accruals, small profit, and audit aggressiveness were used to test the FRQ from different approaches for Borsa Istanbul-listed companies between 2008 ...
Gökberk Can
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Accounting conservatism and life cycle stages in brazilian credit unions
Purpose: This study analyzes how the different stages of the life cycle influence accounting conservatism in Brazilian credit unions, filling a research gap regarding the relationship between organizational maturity and financial reporting quality in ...
Diego Rafael Stüpp +3 more
doaj +1 more source

