Results 81 to 90 of about 427,526 (314)

Life cycle stages and corporate decisions

open access: yesRAM. Revista de Administração Mackenzie
Abstract Purpose: This article aims to examine the influence of life cycle stages on the corporate decisions of Brazilian firms. Originality/value: The study contributes by presenting a scenario of investment, financing, dividend, and cash decisions, revealing patterns and characteristics of the evolution of Brazilian firms throughout their life ...
Marcelly Nóbrega de Medeiros   +1 more
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Antibacterial Activities and Life Cycle Stages of Asparagopsis armata: Implications of the Metabolome and Microbiome. [PDF]

open access: yesMar Drugs, 2023
Parchemin C   +6 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Les réformes de la prévoyance vieillesse vers plus d’égalité et leurs conséquences ambivalentes sur les rapports de genre à la retraite : l’exemple de la Suisse

open access: yesEnfances, Familles, Générations, 2017
Research Framework: Inspired by European debates on the individualization of social rights, the AVS (assurance-vieillesse et survivant suisse [Federal Old-age, Survivors’ and Invalidity Insurance]) introduced individual and universal access to pensions ...
Caroline Henchoz
doaj  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The granuloma in tuberculosis: Dynamics of a host-pathogen collusion

open access: yesFrontiers in Immunology, 2013
A granuloma is defined as an inflammatory mononuclear cell infiltrate that, while capable of limiting growth of Mycobacterium tuberculosis, also provides a survival niche from which the bacteria may disseminate.
Stefan eEhlers   +3 more
doaj   +1 more source

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