Results 51 to 60 of about 435,308 (309)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

LCSA Framework for Assessing Sustainability of Alternative Fuels for Transport Sector

Chemical Engineering Transactions, 2019
Consideration of alternative transport fuels, produced from feedstocks and renewable resources, is inevitable to enhance energy security and alleviate environmental burdens.
Najmul Hoque, Wahidul K. Biswas, Ilyas Mazhar, Ian Howard   +3 more
doaj   +1 more source

Water footprint in the context of sustainability assessment. Report on the application of life cycle based indicators of water consumption in the context of integrated sustainability impact analysis [PDF]

, 2012
Sustainability science explores the interactions between human activities on the Earth’s life support systems. Unless we understand these interactions, we will not be able to design a path towards sustainable development.
BIANCHI Alessandra, BLIGNY Jean-Christophe, BOURAOUI Faycal, CASTELLANI Valentina, DE CAMILLIS Camillo, MUBAREKA Sarah, SALA Serenella, VANDECASTEELE Ine, WOLF Marc-Andree   +8 more
core   +1 more source

The Approach of Life Cycle Sustainability Assessment of Biorefineries

, 2016
A key driver for the necessary sustainable development is the implementation of the BioEconomy, which is based on renewable resources to satisfy its energy and material demand of our society. The broad spectrum of biomass resources offers great opportunities for a comprehensive product portfolio to satisfy the different needs of a BioEconomy.
Jungmeier, G., Hingsamer, M., Steiner, D., Kaltenegger, I., Kleinegris, D., van Ree, R., de Jong, E.   +6 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Sustainability implications of service life on residential buildings – An application of life cycle sustainability assessment framework

Environmental and Sustainability Indicators, 2021
Sustainable building design should consider durability, affordability, resource conservation, intra and inter-generational social equity aspects, and stakeholder’s perspective throughout its service life.
Shahana Y. Janjua, Prabir K. Sarker, Wahidul K. Biswas   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Geotraceability and life cycle assessment in environmental life cycle management: towards sustainability. [PDF]

, 2017
Sustainability is an emerging concept in product chains and integrates environmental, social, and economic aspects during the product's life cycle. Recently, the demand for environmental quality has required information about the products' life cycle ...
BATISTELLA, M., CHUZEL, G., GUELERE FILHO, A., OMETTO, A., VIAU, A.   +4 more
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source