Results 51 to 60 of about 35,003 (262)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Life Cycle Assessment and Life Cycle Costing for the Production of Hydrangeas in Antioquia—Colombia

Agronomy
In the floriculture sector, it has been identified that the use of agrochemicals, fuels, and various raw materials has a significant impact on the environment, and, from an economic point of view, their use improves the quality of life of the people ...
Cindy Natalia Arenas, Ana Patricia Bello, Nicolas Fernando Molina, Jaime Leòn Botero, Mariluz Betancur   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Agricultural life cycle assessment: a system-wide bibliometric research

Agricultural and Resource Economics
Purpose. This paper aims to give a system-wide overview of agricultural life cycle assessment (LCA), based on the understanding of agriculture as a complex providing humanity with food, energy and other vital resources and considering all forms of sector’
Inna Koblianska, Larysa Kalachevska, Ralf Schlauderer   +2 more
doaj   +1 more source

Review of Sustainability Assessment Approaches Based on Life Cycles [PDF]

Sustainability, 2019
Many different approaches have been developed to quantify and evaluate sustainability. Here a review is performed on sustainability assessment based on Life Cycle Thinking, which mostly means Life Cycle Sustainability Assessment (LCSA). Until the end of 2018, 258 publications can be found, from which 146 include a case study.
Christina Wulf, Jasmin Werker, Christopher Ball, Petra Zapp, Wilhelm Kuckshinrichs   +4 more
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Blue Ammonia and the Supply Chain Pioneering Sustainability Assessment for a Greener Future

Energies
With the global shift to sustainability, the energy sector faces pressure to adopt low-carbon solutions. Blue ammonia (BA), derived from natural gas (NG) with carbon capture, presents significant opportunities but requires a holistic sustainability ...
Hussein Al-Yafei, Saleh Aseel, Ahmed Alnouss, Ahmad Al-Kuwari, Nagi Abdussamie, Talal Al Tamimi, Hamad Al Mannaei, Heba Ibrahim, Noor Abu Hashim, Bader Al Delayel, Hagar Nasr   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source