Results 91 to 100 of about 1,707,049 (269)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Performance and characterization of snail adhesive mucus as a bioflocculant against toxic Microcystis

Ecotoxicology and Environmental Safety
Toxic Microcystis blooms are widespread in aquatic bodies, posing major threats to aquatic and human life. Recently, bioflocculants have attracted considerable attention as a promising biomaterial for Microcystis management. In search of a novel organism
Qin Peng, Xinyue Gong, Ruixin Jiang, Na Yang, Ruiting Chen, Binglin Dai, Rui Wang   +6 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

INDUSTRIAL APPLICATIONS OF WILD AND GENETICALLY-MODIFIED STRAINS OF ACETIC ACID BACTERIA [PDF]

Postępy Mikrobiologii, 2018
Lidia Stasiak-Różańska, Milena Kupiec
doaj   +1 more source

Quality-of-Life Evaluation [PDF]

Journal of Pain and Symptom Management, 1998
Cinzia Brunelli, Massimo Costantini, Paola DiGiulio, Michele Gallucci, Flavio Fusco, Guido Miccinesi, Eugenio Paci, Carlo Peruselli, Piero Morino, Massimo Piazza, Marcello Tamburini, Franco Toscani   +11 more
openaire   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

EXOPOLYSACCHARIDE-PRODUCING LACTIC ACID BACTERIA – HEALTH-PROMOTING PROPERTIES AND APPLICATION IN THE DAIRY INDUSTRY [PDF]

Postępy Mikrobiologii, 2019
Anna M. Berthold-Pluta, Antoni St. Pluta, Monika Garbowska, Lidia Stasiak-Różańska   +3 more
doaj   +1 more source

Effectiveness and tolerability of chlormethine gel for the management of mycosis fungoides: a multicenter real-life evaluation. [PDF]

Front Oncol, 2023
Alberti-Violetti S, Ardigò M, Massone C, Pileri A, Sala R, Teoli M, Grandi V, Quaglino P, Pimpinelli N, Berti E.   +9 more
europepmc   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source