Results 121 to 130 of about 2,065,566 (311)

Multicentre cross-sectional clinical evaluation study about quality of life in adults with disorders/differences of sex development (DSD) compared to country specific reference populations (dsd-LIFE)

, 2018
Background: Previous studies in quality of life (QOL) in individuals with disorders/differences of sex development (DSD) have been restricted to subpopulations of the condition.
Rapp, Marion, Marion Rapp, Peter Lee, Baudewijntje P. C. Kreukels, Roehle, Robert, Rapp, M, Nordenstroem, A, Anna Nordenström, Kreukels, Baudewijntje P. C., Bouvattier, Claire, Birgit Köhler, Nordenström, Anna, Thyen, Ute, Lee, P, Koehler, B, Lee, Peter, Köhler, Birgit, Bouvattier, C, Esther Mueller-Godeffroy, on behalf of the dsd-LIFE group, Mueller-Godeffroy, Esther, Robert Roehle, null null, Thyen, U, Ute Thyen, Mueller-Godeffroy, E, Claire Bouvattier, Kreukels, BPC, Kreukels, Baudewijntje P.C., Roehle, R   +29 more
core   +1 more source

Comparative impacts of polyethylene and biodegradable film residues on soil microbial communities and rapeseed performance under field conditions

Frontiers in Microbiology
IntroductionSoil health is critical for sustainable agriculture and food security, however, the accumulation of agricultural mulch film residues in soil raises environmental concerns.
MiaoMiao Xie, MiaoMiao Xie, Maolu Wei, Maolu Wei, Qian Sun, Qian Sun, Ge Wang, Ge Wang, Ting Shen, Ting Shen, Xinyi He, Xinyi He, Dongyan Liu, Dongyan Liu   +13 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Evaluating the Effectiveness of Alcohol and Substance Abuse Services for American Indian/Alaska Native Women

, 2014
The major goal of Phase II of this study was to collect and analyze much-needed descriptive, demographic, social, cultural, and clinical information about women receiving treatment in alcohol and substance abuse treatment centers funded in whole or in ...
University of California, San Francisco, Institute for Health Policy Studies, San Francisco, CA.
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Methods of evaluation of the quality of life in rheumatic diseases

, 2014
The concept of health assessment for a patient is identified with functional status and quality of life in a disease. The obtained results indicate that the assessment made by the patient often differs from the assessment by the physician.
Jacek Polański, Beata Jankowska-Polańska   +1 more
core   +1 more source

Comparative analysis of actinorhizal nodule and associated soil microorganism diversity and structure in three Alnus species

Frontiers in Plant Science
BackgroundDue to the importance of biological nitrogen fixation in terrestrial ecosystems, actinorhizal symbiosis has attracted more and more attention.
Aizi Tong, Wei Liu, Xiaoliang Liu, Junyi Zhu, You Zhou, Jianhua Li   +5 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Unveiling the regulatory mechanism of poly-γ-glutamic acid on soil characteristics under drought stress through integrated metagenomics and metabolomics analysis

Frontiers in Microbiology
It is of utmost importance to understand the characteristics and regulatory mechanisms of soil in order to optimize soil management and enhance crop yield. Poly-γ-glutamic acid (γ-PGA), a stress-resistant amino acid polymer, plays a crucial role in plant
Li Hong, Li Hong, Li Wei, Li Wei, Ge Fanglan, Ge Fanglan, Li Jiao, Li Jiao, Tu Shiheng, Tu Shiheng, Yang Hong, Yang Hong, Ren Yao, Ren Yao, Gong Xinyue, Gong Xinyue, Yao Can, Yao Can   +17 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source