Results 141 to 150 of about 8,948,014 (307)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Floristic study of the pure beech (Fagus orientalis Lipsky) stands in eastern Guilan, Iran

open access: yesیافته‌های نوین در علوم زیستی, 2017
Hyrcanian forests in northern Iran have important tree and shrub elements of Euro-Siberian and rare forest communities, among them beech community widely covers the mountainous forests from Western to Eastern (Gorgan) Hyrcanian region.
Hamid Gholizadeh   +2 more
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Crown organization in reproductive individuals of Quercus robur L. in the western spurs of the Volga upland

open access: yesИзвестия высших учебных заведений. Поволжский регион: Естественные науки
Background. In recent centuries on the East European Plain massive degeneration of oak forests has been in progress. This is caused by a complex of climatic and anthropogenic factors. Since Quercus robur L. is a key species it seems to be necessary to
M.N. Stamenov
doaj   +1 more source

Flora, life form and chorological studies of riparian forest along Safa-Rud riverside in Ramsar forest between altitudinal ranges 350 to 2400 m a.s.l. [PDF]

open access: yesمجله جنگل ایران, 2015
Riparian forests maintain diverse vegetation structure through the influence of various types, intensities, and frequencies of disturbance promoted by fluvial and geomorphic processes.
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Presentation of flora, life form and chorotype of plants in Sadetarik Forest Park, Roudbar, Guilan [PDF]

open access: yesمجله جنگل ایران, 2012
The Sadetarik Forest Park with an area about 614.85 ha is located at south-east of Rasht city. The aim of this research was to study the floristic composition, life forms and chorotype in Sadetarik Forest Park.
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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