FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
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CONVERSATION WITH HIMSELF AS MENTAL STATE, ITS STRUCTURE, FORM AND IMPACT ON HUMAN LIFE
, 2021 S.E. Kuzenko, L.R. Gaisina, R.R. Muzirov
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
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Life history of a small form of the plethodontid salamander Desmognathus quadramaculatus [PDF]
, 2003 Christopher K. Beachy, Richard C. Bruce
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DIVERSIDADE MORFOLÓGICA E FORMAS DE VIDA DAS ARACEAE NO PARQUE ESTADUAL DO RIO DOCE, MINAS GERAIS
RodriguésiaRESUMO Araceae apresenta uma morfologia e terminologia específica, que pode ocasionar dificuldades de compreensão. Além disso, alguns conceitos adotados para a família, são discordantes entre os especialistas do grupo.
Lívia Godinho Temponi +3 more
doaj +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
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Responses to Airborne Ozone and Soilborne Metal Pollution in Afforestation Plants with Different Life Forms. [PDF]
Plants (Basel), 2023 Günthardt-Goerg MS +2 more
europepmc +1 more source
Is Wittgenestein a Believing Person? A Second Look at the Theological Epistemology Related to Him [PDF]
حکمت و فلسفه, 2014 Regarding Wittgensteinian view towards fideism, two questions have been left unanswered: Firstly, has Wittgenstein explicitly defended fideism? And secondly, can fideism be deducted from his thoughts?
mostafa hosseini golkar +1 more
doaj
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
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