Results 131 to 140 of about 2,069,818 (312)
Life history and project: life history as a project and "life histories" attending to projects
, 1999 Twenty years of reflections in and about procedures of "life histories in formation" allow the production of a synthesis about their contributions, and the understanding of the development from the point of view of the developing subjects. They also provide an understanding of the aspirations of knowledge about the contexts of usage of biographical ...
openaire +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
, 1951 Letter from Life Magazine to D. W. Kempner apologizing that he has not received his copy of "LIFE'S Picture History of World War II" yet and saying that one will be sent to him after they check their ...
Rogers, Bruce, Life Magazine
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Life-history traits of the virulent and avirulent lineages
, 2016 Life-history traits of the virulent and avirulent ...
Delphine Eoche-Bosy (3276543) +4 more
core +1 more source
Life Histories, or History Comes to Life [PDF]
Notes and Records: the Royal Society Journal of the History of Science, 2018 openaire +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
On the intertemporal allocation of consumption, mortality and life-history strategies [PDF]
This paper studies the bio-evolutionary origin of time preference. By examining human life-history strategies, it demonstrates that time discounting and mortality reflect the age-variation in the value of survival, which in turn depends on future ...
Junji Kageyama
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source