Results 181 to 190 of about 15,880,890 (357)

Erratum to: Development of novel multiplex microsatellite polymerase chain reactions to enable high-throughput population genetic studies of Schistosoma haematobium

Parasites & Vectors, 2015
B. L. Webster, M. Rabone, T. Pennance, A. M. Emery, F. Allan, A. Gouvras, S. Knopp, A. Garba, A. A. Hamidou, K. A. Mohammed, S. M. Ame, D. Rollinson, J. P. Webster   +12 more
doaj   +1 more source

Eutrophication Reshapes Microbial Communities and Life-History Strategies in the Riverine Ecosystems. [PDF]

Environ Microbiol Rep
Li H, Fu J, Fan X, He Z, Wang Y, Yang S, Wu J, Wu L, Zhou J.   +8 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Environmental adversity, life-history traits and cognitive functioning in children and adolescents. [PDF]

R Soc Open Sci
Jin Z, Guo H, Lu H, Chang L.
europepmc   +1 more source

Implications of life-history strategies for obesity

Proceedings of the National Academy of Sciences of the United States of America, 2017
J. Maner, A. Dittmann, Andrea L Meltzer, J. McNulty   +3 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Inbreeding Depression Across Multiple Life-History Traits in a Long-Lived Mammal. [PDF]

Mol Ecol
Auclair L, Vanpé C, Chapron G, Quenette PY, Robert A.   +4 more
europepmc   +1 more source

Fundamental difference in life history traits of two species of Cataglyphis ants. [PDF]

, 2006
Markus Knaden, Rüdiger Wehner
openalex   +1 more source

A life-history theory perspective on obesity

Behavioral and Brain Sciences, 2016
Andrea G. Dittmann, Jon K. Maner
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source