Results 201 to 210 of about 10,801,097 (341)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Growth, development, and life history of a mass-reared edible insect, Gryllodes sigillatus (Orthoptera: Gryllidae). [PDF]

J Econ Entomol
Kong JD, Ritchie MW, Vadboncoeur É, MacMillan HA, Bertram SM.   +4 more
europepmc   +1 more source

Some words on the life-history of Lycopods1

, 1887
MELCHIOR TREUB
openalex   +2 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

An evolutionary medicine and life history perspective on aging and disease: Trade-offs, hyperfunction, and mismatch. [PDF]

Evol Med Public Health
Aronoff JE, Trumble BC.
europepmc   +1 more source

Studies in life-histories of Australian Diptera Brachycera. Part i. Stratiomyiidae. No. 2. Further experiments in the rearing of Metoponia rubriceps

, 1921
Vera Irwin-Smith
openalex   +2 more sources

Brain ontogeny and life history in Pleistocene hominins

Philosophical Transactions of the Royal Society B: Biological Sciences, 2015
J. Hublin, Simon Neubauer, P. Gunz
semanticscholar   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Artificial selection for adult predation survival affects life history and morphology in guppies (<i>Poecilia reticulata</i>). [PDF]

Sci Adv
De Waele H, Vega-Trejo R, Vila-Pouca C, Noordenbos J, Phillips E, Pollux BJA, Kotrschal A.   +6 more
europepmc   +1 more source

Studies on the life-history of Protozoa

, 1902
Gary N. Calkins
openalex   +2 more sources