Results 211 to 220 of about 2,069,818 (312)

The Marsupial Database: A comprehensive dataset on the ecology and life history of American and Australasian marsupials. [PDF]

Ecology
Ferreira MS, Rossi RC, Batista S, Sena K, Bairos-Novak KR, Shoma SF, Leiner NO, Astúa D, Coulson G, Fisher DO, Harrison ND, Willmer JNG, Silva GR, Cupolillo G, Vieira MV, Vieira EM, Püttker T, Figueiredo MSL, Dickman CR.   +18 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Harshness Predicts Reproduction in Brazilian Municipalities and US Counties: A Life History Theory Approach. [PDF]

Evol Psychol
Koehler VB, Rutherford MD.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Use of a self-completed life history calendar in relation to data completeness and accuracy. [PDF]

BMC Med Res Methodol
Yu J, Jantchou P, Gong RN, Nicolau B, Madathil S, Mesidor M, Rousseau MC.   +6 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Experimental evidence of life history trade-offs during ultra-endurance physical activity. [PDF]

Evol Hum Sci
Longman DP, Murray A, Brown EL, Lewis C, Millis RM, Nowak TJ, Udquim KT, Muehlenbein MP, Wells JCK, Stock JT.   +9 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Biodiversity conservation requires consideration of different life history stages. [PDF]

Proc Natl Acad Sci U S A
Song YF, Liu XL, Liu JJ, Li QQ, Li XQ, Lu WZ, Zhou WW, Yuan ZY.   +7 more
europepmc   +1 more source