Results 91 to 100 of about 2,758,289 (295)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Life History through Communications Theory
Japanese Sociological Review, 1992 Life history can be considered as a collaboration produced by an interviewer/listener and an interviewee/teller. We examine it through the communications theory proposed by G. Bateson. According to this theory, life history contains two levels : the relation-level and the content-level.
openaire +2 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Liberalism, Republicanism And The Spirit Of American Politics: A Critique Of Sandel [PDF]
, 1997 Michael Sandel sees Rawls' liberal theory of justice as abstractly uncomprehensive of another, republican view of the essential relation of political life to moral culture.
Peddle, David
core
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Do Slower Life History Strategies Reduce Sociodemographic Sex Differences?
Journal of Methods and Measurement in the Social Sciences, 2015 This study examines the relations between sociodemographic sex differences and life history strategies in the populations of Mexican States. Sex differences in anatomy and behavior was measured with traits such as educational achievement, mortality, and ...
Cindy Elizabeth Chavarria Minera +2 more
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
The Life and Legacy of James I, King of England [PDF]
, 2020 As the first member of the Stuart line to hold the Kingdoms of England, Ireland, and Scotland under his suzerainty, the life and reign of King James I was always going to mark a serious turning point in the histories of the lands under his control.
Arbaugh, Nicholas S.
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source