Results 101 to 110 of about 2,758,289 (295)

Effects of early-life environmental stress on risk-taking tendency of adolescents in rural areas of southwestern China

Frontiers in Psychiatry
IntroductionAdolescence is a critical developmental phase characterized by increased risk-taking behaviors, which are not inherently maladaptive. According to life history theory, individuals raised in harsh and unpredictable environments are more likely
Jing Wu, Qiaobing Wu
doaj   +1 more source

Predicting Moffitt's Developmental Taxonomy of Antisocial Behavior Using Life History Theory: A Partial Test of the Evolutionary Taxonomy. [PDF]

Evol Psychol, 2023
Nedelec JL, DiRienzo F.
europepmc   +1 more source

2. Toynbee and the Cyclical Pattern of History

, 1958
There has been recently a return on the part of some writers to the Greek theory that the course of history follows a cyclical pattern. An important motivation for this return is the conviction that neither the theory of progress nor the classical ...
Bloom, Robert L., Crapster, Basil L., Dunkelberger, Harold L., Glatfelter, Charles H., Mara, Richard T., Richardson, Norman E., Schubart, W. Richard   +6 more
core  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

The Future of Systematics: Tree-Thinking Without the Tree [PDF]

, 2012
Phylogenetic trees are meant to represent the genealogical history of life and apparently derive their justification from the existence of the tree of life and the fact that evolutionary processes are tree-like.
Velasco, Joel D.
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Theory, Method and British Political Life History [PDF]

Political Studies Review, 2011
The British tradition of political life history has six conventions: ‘tombstone’ biography, separation of public and private lives, life without theory, objective evidence and facts, character and storytelling. I describe each in turn and review the main debates in the tradition before turning to the swingeing critique by ‘the interpretive turn ...
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Safe Periods and Safe Activities: Two Phenological Responses to Mortality

Ecology and Evolution
Phenology is often thought to evolve mainly in response to food availability, yet recent studies have focused on predation. Predation may explain apparent mismatches between phenology and resources. One type of phenological response to predation involves
Théo Constant, F. Stephen Dobson, Sylvain Giroud, Caroline Habold   +3 more
doaj   +1 more source