Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Micronekton of the North Pacific [PDF]
, 2005 1. INTRODUCTION 1.1 Working Group History 2. SPECIES COMPOSITION AND DISTRIBUTION PATTERNS RELATED TO WATER MASSES 2.1 Mesopelagic Fishes 2.1.1 Dominant families 2.1.2 Large-scale feeding and/or spawning migration or expatriation ...
core
Insights into life history theory: a brood size manipulation on a southern hemisphere species, Tachycineta leucorrhoa , reveals a fast pace of life [PDF]
, 2014 Florencia Bulit +2 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Life history traits explain the intra-seasonal abundance pattern of rare land snail species Vertigo moulinsiana: bridging the theory-application gap [PDF]
Anna M. Lipińska +2 more
openalex +3 more sources
Biography and Broken Barriers: Melville’s Use of Personal Experience and Social Groups to Achieve Commentary in \u3cem\u3eTypee\u3c/em\u3e and \u3cem\u3eRedburn\u3c/em\u3e [PDF]
, 2015 Melville’s texts continue to be relevant to a contemporary readership well over a century since original publication, as his words not only illuminate and examine nineteenth century experiences, but also present concepts and ideas that continue to be ...
Quigley, Katelyn
core +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Archaeology, demography and life history theory together can help us explain past and present population patterns. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2021 Shennan S, Sear R.
europepmc +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat +18 more
wiley +1 more source