Results 71 to 80 of about 2,716,139 (331)

Computed tomography shows high fracture prevalence among physically active forager-horticulturalists with high fertility

eLife, 2019
Modern humans have more fragile skeletons than other hominins, which may result from physical inactivity. Here, we test whether reproductive effort also compromises bone strength, by measuring using computed tomography thoracic vertebral bone mineral ...
Jonathan Stieglitz, Benjamin C Trumble, HORUS Study Team, Caleb E Finch, Dong Li, Matthew J Budoff, Hillard Kaplan, Michael D Gurven   +7 more
doaj   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

Endogenous ROS Levels in C. Elegans Under Exogenous Stress Support Revision of Oxidative Stress Theory of Life-History Tradeoffs [PDF]

, 2014
Background: The oxidative stress theory of life-history tradeoffs states that oxidative stress caused by damaging free radicals directly underpins tradeoffs between reproduction and longevity by altering the allocation of energetic resources between ...
Denver, Dee R., Estes, Suzanne, Latta, Leigh C., IV, Smith, Samson W.   +3 more
core   +2 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Do Slower Life History Strategies Reduce Sociodemographic Sex Differences?

Journal of Methods and Measurement in the Social Sciences, 2015
This study examines the relations between sociodemographic sex differences and life history strategies in the populations of Mexican States. Sex differences in anatomy and behavior was measured with traits such as educational achievement, mortality, and ...
Cindy Elizabeth Chavarria Minera, Aurelio José Figueredo, Laura Gail Lunsford   +2 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Fundamental Molecules of Life are Pigments which Arose and Evolved to Dissipate the Solar Spectrum

, 2014
The driving force behind the origin and evolution of life has been the thermodynamic imperative of increasing the entropy production of the biosphere through increasing the global solar photon dissipation rate.
Michaelian, Karo, Simeonov, Aleksandar
core   +2 more sources

“The weight we carry in our backpack is not the weight of our books, it’s the weight of our community!”: Latinas negotiating identity and multiple roles [PDF]

, 2020
In the United States, out of 100 Latina/o elementary students, only 0.3 will complete a doctorate degree. Latinas/os/x as a fast-growing minority population in the United States continue to be underrepresented in higher education. The underrepresentation
Camargo Gonzalez, Lorena
core  

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Material security, life history, and moralistic religions: A cross-cultural examination. [PDF]

PLoS ONE, 2018
Researchers have recently proposed that "moralistic" religions-those with moral doctrines, moralistic supernatural punishment, and lower emphasis on ritual-emerged as an effect of greater wealth and material security.
Benjamin Grant Purzycki, Cody T Ross, Coren Apicella, Quentin D Atkinson, Emma Cohen, Rita Anne McNamara, Aiyana K Willard, Dimitris Xygalatas, Ara Norenzayan, Joseph Henrich   +9 more
doaj   +1 more source