Results 171 to 180 of about 8,942,242 (366)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Early-life prediction of school-age asthma among recurrent Wheezers in preschoolers: The WHEEP study. [PDF]

Pediatr Allergy Immunol
Karramass T, Mancino E, Balemans W, Brouwer M, De Groot E, Landstra AM, Merkus PJFM, Niers LEM, Vaessen-Verberne A, van Klaveren D, Vermeulen H, Verwaal M, Pijnenburg M, Duijts L.   +13 more
europepmc   +1 more source

A Unified Life Prediction Model for 316l Austenitic Stainless Steel Under Isothermal, Thermomechanical Fatigue and Creep-Thermomechanical Fatigue Loadings

Peng Yin, Wei Zhang, Qiaofa Yang, Xinghui Chen, Fei Liang, Le Chang, Changyu Zhou   +6 more
openalex   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Bearing remaining useful life prediction based on optimized VMD and BiLSTM-CBAM. [PDF]

PLoS One
Liu W, Liu S.
europepmc   +1 more source

Fatigue life uncertainty prediction using the Monte Carlo and Latin hypercube sampling techniques under uniaxial and multiaxial cyclic loading

, 2022
Aleksander Karolczuk, Marta Kurek
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Efficient Channel Attention-Gated Graph Transformer for Aero-Engine Remaining Useful Life Prediction. [PDF]

ACS Omega
Chen C, Li M, Shi J, Yue D, Shi G, Feng L, Churakova AA, Alexandrov IV.   +7 more
europepmc   +1 more source

Lung Body Plethysmography: From Functional to Clinical Aspects for Prediction of Quality of Life in Patients with Chronic Pulmonary Obstruction [PDF]

, 2019
Roxana Maria Nemeş, Florentina Furtunescu, I Tudorache, Tudor Harsovescu, Alexandra Floriana Nemeş, Mironela Pîrnău   +5 more
openalex   +1 more source

A life-threatening bleeding prediction model for immune thrombocytopenia based on personalized machine learning: a nationwide prospective cohort study

, 2023
Zhuo‐Yu An, Yejun Wu, Yu Hou, Heng Mei, Weixia Nong, Wenqian Li, Hu Zhou, Ru Feng, Jianping Shen, Jun Peng, Hai Zhou, Yi Liu, Yongping Song, Linhua Yang, Meiyun Fang, Jianyong Li, Yunfeng Cheng, Peng Liu, Yajing Xu, Zhao Wang, Yi Luo, Zhen Cai, Hui Liu, Jingwen Wang, Juan Li, Xi Zhang, Zimin Sun, Xiaoyu Zhu, Xin Wang, Rong Fu, Liang Huang, Shaoyuan Wang, Tonghua Yang, Liping Su, Liangming Ma, Xiequn Chen, Dai‐Hong Liu, Hongxia Yao, Jia Feng, Hongyu Zhang, Ming Jiang, Zeping Zhou, Wensheng Wang, Xuliang Shen, Yangjin Baima, Yueying Li, Qian‐Fei Wang, Qiu-Sha Huang, Hai‐Xia Fu, Xiaolu Zhu, Yun He, Qian Jiang, Hao Jiang, Lu Jin, Xiaosu Zhao, Ying‐Jun Chang, Tao Wu, Yaozhu Pan, Lin Qiu, Da Gao, A-Rong Jin, Wei Li, Sujun Gao, Lei Zhang, Ming Hou, Xiao‐Jun Huang, Xiaohui Zhang   +66 more
openalex   +1 more source