Results 71 to 80 of about 3,107 (167)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Spatial and life history variation in a trait-based species vulnerability and impact model.

PLoS ONE
Anthropogenic pressures threaten biodiversity, necessitating conservation actions founded on robust ecological models. However, prevailing models inadequately capture the spatiotemporal variation in environmental pressures faced by species with high ...
Aharon G Fleury, Casey C O'Hara, Nathalie Butt, Jaime Restrepo, Benjamin S Halpern, Carissa J Klein, Caitlin D Kuempel, Kaitlyn M Gaynor, Lily K Bentley, Anthony J Richardson, Daniel C Dunn   +10 more
doaj   +1 more source

Biological functions at high pressure: transcriptome response of Shewanella oneidensis MR-1 to hydrostatic pressure relevant to Titan and other icy ocean worlds

Frontiers in Microbiology
High hydrostatic pressure (HHP) is a key driver of life's evolution and diversification on Earth. Icy moons such as Titan, Europa, and Enceladus harbor potentially habitable high-pressure environments within their subsurface oceans. Titan, in particular,
Judy Malas, Daniel C. Russo, Olivier Bollengier, Michael J. Malaska, Rosaly M. C. Lopes, Fabien Kenig, D'Arcy R. Meyer-Dombard   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

SURVIVING PRESSURES AND INNER CONFLICTS:WINSTON’S PARADOXICAL REALMS IN ORWELL’S 1984

Lire Journal
People are destined to live with pressures, and some deal with them by conducting paradoxes to survive. However, consciously or unconsciously people construct and conduct paradoxes to live. Paradox is a contradiction of two things. Winston Smith, has to
Vicky Firmansyah, RB. Edi Pramono
doaj   +1 more source

CALCULATION METOD FOR THE EVALUATION OF INFLUENCE OF TOOTH ENGAGAMENT PARITY IN CONICAL SPUR GEAR ON CONTACT PRESSURES, WEAR AND DURABILITY [PDF]

Applied Computer Science, 2016
The paper presents the results of research undertaken to determine maximum contact pressures, wear and life of conical gears, taking account gear technological correction, tooth engagement and wear-generated changes in curvature of their involute profile.
Myron CHERNETS, Yuriy CHERNETS
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

AN ANALYSIS OF TRANSLATION SHIFT IN THE MERRY RIANA’S DARE TO DREAM BIG BOOK

Lire Journal
People are destined to live with pressures, and some deal with them by conducting paradoxes to survive. However, consciously or unconsciously people construct and conduct paradoxes to live. Paradox is a contradiction of two things. Winston Smith, has to
Gerensius Levi, Ni Made Verayanti Utami
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source