Results 151 to 160 of about 8,967,818 (362)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Sociologie Românească, 2016 This paper investigates the contribution of the socioeconomic status and access to healthcare toward subjective health in Romania, when compared to two groups of countries: the Central and Eastern European, and the Nordic and Western countries. This data
Iuliana Precupețu, Cosmina-Elena Pop
doaj
Journal of Experimental OrthopaedicsPurpose Total knee arthroplasty (TKA) represent a well‐established treatment for advanced osteoarthritis. Despite advancements in implant design and materials, the impact of stress shielding on bone mineral density (BMD) and its relationship with implant
Giulio Senesi +7 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Improving the Quality of Professional Life
, 2004 Kathleen Young, Whitney Boling
openalex +2 more sources
Symptoms of anxiety and depression and health-related quality of life in women with severe obesity and polycystic ovary syndrome and the effect of a one year weight loss intervention [PDF]
, 2023 Josefin Kataoka +6 more
openalex +1 more source
HEMOGLOBIN A1C IMPROVEMENTS AND BETTER DIABETES-SPECIFIC QUALITY OF LIFE AMONG PARTICIPANTS COMPLETING DIABETES SELF-MANAGEMENT PROGRAMS: A NESTED COHORT STUDY [PDF]
, 2018 Background: Numerous primary care innovations emphasize patient-centered processes of care. Within the context of these innovations, greater understanding is needed of the relationship between improvements in clinical endpoints and patient-centered ...
Khanna, Abhinav
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source