Results 211 to 220 of about 8,967,818 (362)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of enhanced recovery after surgery nursing on gastrointestinal recovery function and life quality in patients laparoscopic cholecystectomy. [PDF]

World J Gastrointest Surg
Sun ZY, Ye L, Mao YY, Liang L.
europepmc   +1 more source

Effects of parasitic infections on clinical outcomes, self-rated quality of life and physical fitness in Côte d'Ivoire [PDF]

, 2014
Eveline Hürlimann
openalex   +1 more source

Stress and Quality of Life among Young Adults During Covid-19 Pandemic in Kuala Selangor

, 2023
Balqis Efrina Basri, Nurul Izzati Sujak, Roslinda Isa   +2 more
openalex   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Translation, cross-cultural adaptation and validation of an Afan Oromo version of the Dermatology Life Quality Index in individuals with cutaneous leishmaniasis in Ethiopia. [PDF]

Skin Health Dis
Wendimu DE, Daba DB, Jira SC, Hailemichael Y, Alemu AY, Mohammed AB, Mohammed FS, Doni SN, Aragaw YK, Degefa MB, Sherefa N, Kassa FA, Nigusse T, Beyene ET, Cherkose T, Lambert SM, Marks M, Walker S, Gadisa E.   +18 more
europepmc   +1 more source

SAT0394 POSSIBLE POTENTIAL INTERACTIONS BETWEEN OBESITY, QUALITY OF LIFE, PSYCHOLOGICAL STATUS AND CLINICAL PARAMETERS IN PSORIATIC ARTHRITIS [PDF]

, 2019
Kevser Gök, Kemal Nas, Erkan Kılıç, Betül Sargın, Sevtap Acer Kasman, Hakan Alkan, Nilay Şahin, Gizem Cengiz, Nihan Cüzdan, İlknur Albayrak Gezer, Dilek Keskin, Cevriye Mülkoğlu, Hatice Resorku, İsmihan Sunar, Ajda Bal Hastürk, Mehmet Tuncay Duruöz, Okan Küçükakkaş, Ozan Volkan Yurdakul, Meltem Alkan Melikoğlu, Yıldıray Aydın, Fikriye Figen Ayhan, Hatice Bodur, Mustafa Çalış, Erhan Çapkın, Gül Devrimsel, Sami Hizmetli, Ayhan Kamanlı, Yaşar Keskin, Hilal Kocabaş, Öznur Kutluk, Nesrin Şen, Ömer Faruk Şendur, İbrahim Tekeoğlu, Murat Toprak, Sena Tolu, Tiraje Tuncer   +35 more
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source