Results 71 to 80 of about 2,423,258 (261)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Life in Science and the Science of Life by Aleksandr Shmuk

open access: yesNasledie Vekov, 2020
Рецензируется книга доктора биологических наук, академика РАН А.Х. Шеуджена и доктора исторических наук А.Н. Еремеевой, посвященная жизни и творчеству известного советского агрохимика и биохимика, академика ВАСХНИЛ Александра Александровича Шмука (1886–1945). Анализ отечественной и зарубежной литературы, научных и общественно-политических периодических
openaire   +2 more sources

Science - Sense of Life [PDF]

open access: yesEuropean Financial and Accounting Journal, 2009
Dear readers, European Financial and Accounting Journal boasts about attribute "scientific". Therefore let me put a question whether people thirst for science. Most of us probably answered yes. From medical sciences we expect new remedies for old and new diseases, from technical research we hope for new inventions which will make our labor and personal
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The life devoted to science

open access: yesІнтродукція Рослин, 2010
The life and scientific work botanist, brooder of fruit plants S.V. Klymenko are retraced.
N.V. Chuvikina
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A consideration of life sciences.

open access: yesJournal of Information Processing and Management, 1987
本稿は, 第22回日本科学技術情報センター丹羽賞の授賞式における特別講演の収録である。生物を一つの情報システムと見なし, その仕組みを説く。例えば, 遺伝子でたんぱく質をつくると, 出来たホルモン, 酵素といった「物」自身がすべて情報を持つ。遺伝子は動くことなく, 情報を持った「物」が体中を巡ることにより, 生物のシステムは動く。このような生命科学の視点から, 情報を「心」と「物」とを結びつけるものとして考え直す必要があろうと問題提起する。
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Partnering with Life Science Alliance

open access: yesMolecular Systems Biology, 2018
Molecular Systems Biology is partnering with the new open‐access journal Life Science Alliance, an initiative by three major not‐for‐profit science organizations. An informed transfer process was established with our partner to provide authors with clear
Thomas Lemberger
doaj   +1 more source

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