Results 61 to 70 of about 6,108,300 (348)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Comment: The Place of Death in the Quality of Life [PDF]
Statistical Science 2006, Vol. 21, No. 3, 313-316, 2006 Comment on The Place of Death in the Quality of Life [math.ST/0612783]
arxiv +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Preface: New trends in first-passage methods and applications in the life sciences and engineering [PDF]
, 2020 This is the preface to the special issue of the Journal of Physics A: Mathematical and Theoretical, entitled "New trends in first-passage methods and applications in the life sciences and engineering"
arxiv +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
Deliberations on the Life Sciences: Pitfalls, Challenges and Solutions
Journal of Deliberative Democracy, 2011 In this article I sketch several versions of the deliberative approach and then discuss five problems which confront a deliberative ethicist of contemporary problems of the life sciences, in particular about food, nature and agriculture.
Michiel Korthals
doaj +2 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Artificial Intelligence in Medicine: Preparing for the Confirmed Inevitable. Theoretical and Methodological Considerations [PDF]
Journal of Systemics, Cybernetics and Informatics, 2019 The AI in Medicine project began with a simple yet complex and multilevel question. In late 2017, prompted by direct experience of researching human-machine interchanges, we asked whether the traditional principles of interaction between a physician and ...
Andrey V. Rezaev, Piotr K. Yablonskiy
doaj
Linked Environment Data for the Life Sciences [PDF]
arXiv, 2010 Environment Agencies from Europe and the US are setting up a network of Linked Environment Data and are looking to crosslink it with Linked Data contributions from the life sciences.
arxiv