Results 61 to 70 of about 2,264,386 (292)

Purification tags markedly affect self‐aggregation of CPEB3

open access: yesFEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito   +6 more
wiley   +1 more source

Pragmatic, Interdisciplinary Perspectives on Blockchain and Distributed Ledger Technology: Paving the Future for Healthcare

open access: yesBlockchain in Healthcare Today, 2018
Background: Blockchain and distributed ledger technology is a disruptive force in healthcare. Methods: This article provides a globally relevant, interdisciplinary perspective intended to aid disparate group of actors, participants, and users that ...
Ron Ribitzky   +8 more
doaj   +1 more source

Science and Life [PDF]

open access: yesNature, 1954
The Nature of Science and Other Lectures By Edwin Hubble. Pp. viii + 83 + 2 plates. (San Marino, Calif.: The Huntington Library, 1954.) 2 dollars.
openaire   +2 more sources

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

The Sustainable Development of Zootechnical Sciences in the Context of Life Sciences and the Perspectives of Zootechnical Engineers in the Innovative Concept of Eco-Bio-Economic Engineering

open access: yesScientific Papers Animal Science and Biotechnologies, 2023
Zootechnical sciences represent a well defined concept since the notion of “Zootechnics” has been in use (in the second part of the 19th c.) and they continued to develop throughout the 20th century and they have acquired new insights in the early 21st c.
Alexandru T. Bogdan   +2 more
doaj  

Microfluidics and the Life Sciences

open access: yesScience Progress, 2012
The field of microfluidics, often also referred to as “Lab-on-a-Chip” has made significant progress in the last 15 years and is an essential tool in the development of new products and protocols in the life sciences. This article provides a broad overview on the developments on the academic as well as the commercial side.
Claudia Gärtner, Holger Becker
openaire   +3 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Scientometric Analysis: An Emerging Tool in Veterinary and Animal Scientific Research

open access: yesAnimals
The present study is an evaluation of published papers in the field of scientometrics–bibliometrics in veterinary or animal studies. The objective was the quantitative evaluation of the scientific content and the bibliometric details of papers that had ...
Georgia A. Vaitsi   +6 more
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

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