Results 31 to 40 of about 39,862 (302)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

A City for All: The Future of Human Settlements in Latin America and the Caribbean

open access: yes, 1996
The report presents a regional synopsis on the state of urban management in Latin America and the Caribbean for participants of the Second United Nations Conference on Human Settlements (Habitat II) in Istanbul (1996).
Inter-American Development Bank
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Spatial organization of the settlement network of the municipality of Čačak and tendencies of its development [PDF]

open access: yesGlasnik Srpskog Geografskog Društva, 2013
The balanced and sustainable development of the functional area of Čačak is a precondition for greater integration of geospace. Based on the fact that settlements are the most striking elements of the cultural landscape and they are the holders ...
Nikolić Teodora
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

De la huanca a la estela: la formación de los asentamientos permanentes tempranos (1400 ANE-350 DNE) de la cuenca norte del Titicaca

open access: yesBulletin de l'Institut Français d'Études Andines, 2011
This paper synthesizes the historical trajectory of the altiplano societies of the northern Titicaca Basin, Department of Puno, Peru. These societies began as permanent village settlements organized at the community level and then developed into state ...
Henry Tantaleán, María Ysela Leyva
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Amish Settlements across America: 2013 [PDF]

open access: yes, 2019
This short research report is based upon previous editions of “Amish Settlements across North America,” which was published periodically in Family Life.
Donnermeyer, Joseph, Luthy, David
core   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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