Results 171 to 180 of about 8,857,148 (250)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Enhancing Students' Life Skills Development

, 2003
Lau, P.S.Y, Lee, KM, Chan, R.M.C, Shek, P.M.K, Hui, EKP, Yuen, MT   +5 more
core  

Validation of a Locally Developed Life Skills Development Package (the Manohari Module) for Adolescents in Sri Lanka: Evidence From Expert Review and Adolescent Feedback. [PDF]

Cureus
Coonghe PA, Ganeshan M, Surenthirakumaran R, Mathanraj CJ, Navaneetham N, Hensman G, Kajendran K.   +6 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

PROTOCOL: Life Skills Education and Psychosocial Interventions for Anxiety and Depression in Forcibly Displaced Persons in LMICs: A Systematic Review. [PDF]

Campbell Syst Rev
Duke AEE, Harri BI, Crider R, Liebenberg L, Orji R, Eboreime E.   +5 more
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Efficacy of a Mobile Phone-Based Life-Skills Training Program for Addiction Prevention Optimized Among Adolescents With Low Program Engagement: Cluster-Randomized Controlled Trial. [PDF]

JMIR Mhealth Uhealth
Haug S, Boumparis N, Studhalter O, Wenger A, Schaub MP, Kiselev N.   +5 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Measuring life skills among Veterans: A systematic review of published instruments. [PDF]

J Mil Veteran Fam Health
Mah JC, Jassal T, Mikhail D, Hoppe T, Herniman D, Guévremont B, Le Scelleur H, Couban RJ, Busse JW, Zeraatkar D.   +9 more
europepmc   +1 more source