Results 141 to 150 of about 9,584,915 (340)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Traits of a mussel transmissible cancer are reminiscent of a parasitic life style. [PDF]

Sci Rep, 2021
Burioli EAV, Hammel M, Bierne N, Thomas F, Houssin M, Destoumieux-Garzón D, Charrière GM.   +6 more
europepmc   +1 more source

And None for Gretchen Weiners

, 2013
In the four years I’ve spent at Gettysburg College, it’s safe to say that my experience has been largely influenced by my membership in Greek Life. I’ve developed a personal leadership style and feel accomplished by the strong relationships I built with ...
Center for Public Service,
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Determining the combined effects of three weeks of consumption of HMB supplement and one session of extreme eccentric resistance exercise on the expression rates of myoG and CD56 genes in satellite cells

Revista Brasileira de Nutrição Esportiva, 2019
The purpose of the present study was to determine the combined effects of consumption of HMB-FA supplement and one session of extreme Eccentric resistance training on the rate of activation of the satellite cells of mature male rats.
Elias Kowsari, Alireza Asgari, Hossein Shirvani, Behzad Bazgir, Mostafa Rahimi   +4 more
doaj  

Clinical and life style factors related to the nighttime blood pressure, nighttime dipping and their phenotypes in Korean hypertensive patients. [PDF]

Clin Hypertens, 2023
Kim BS, Kim JH, Kim W, Kim WS, Park S, Lee SJ, Kim JY, Lee EM, Ihm SH, Pyun WB, Shin JH, Shin J.   +11 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

the Effect different type of dual task balance training on balance and cognitive function of older adults [PDF]

Journal of Kerman University of Medical Sciences
Background: The purpose of this research is to investigate the effectiveness of different training methods of dual task on balance and cognitive function in the elderly.Method: The participants in this study were 36 elderly individuals aged 65 years and ...
hesam iranmanesh, hossein shirvani, Amin Amini, Alireza Shamsoddini, vahid Sobhani   +4 more
doaj  

Cardiac Rehabilitation and Healthy Life-Style Interventions: Rectifying Program Deficiencies to Improve Patient Outcomes.

Journal of the American College of Cardiology, 2016
C. Lavie, R. Arena, B. Franklin
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source