Results 241 to 250 of about 2,350,551 (305)
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
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Life philosophy and Life style
Social Indicators Research, 1984Two categories of values are distinguished by their psychological functions. Life philosophy values secure a person's sense of personal identity; they are held regardless of what anyone else thinks of his value choice. Life style values secure a person's sense of social identity; they are held precisely because of what others think of his value choice.
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Industrial and Commercial Training, 1974
The geographic, economic and social mobility of people today requires that many must be able to adapt or adopt various life styles in accordance with their surroundings and integrity. Today, many people need to be multi‐cultural so they can succeed and survive in ethnic, commercial and other milieux in rapid sequence, often each day.
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The geographic, economic and social mobility of people today requires that many must be able to adapt or adopt various life styles in accordance with their surroundings and integrity. Today, many people need to be multi‐cultural so they can succeed and survive in ethnic, commercial and other milieux in rapid sequence, often each day.
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1987
‘Seabird’ is a rather loose term traditionally used to cover those birds which obtain at least part of their food from the sea, not simply by wading into it as do shorebirds, but by travelling some distance over its surface; in addition, they typically breed on offshore islands or coastal areas.
R. W. Furness, P. Monaghan
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‘Seabird’ is a rather loose term traditionally used to cover those birds which obtain at least part of their food from the sea, not simply by wading into it as do shorebirds, but by travelling some distance over its surface; in addition, they typically breed on offshore islands or coastal areas.
R. W. Furness, P. Monaghan
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Regional Studies, 1981
Glyptis S. A. (1981) Leisure life-styles, Reg. Studies 15, 311–326. This paper examines the life-styles and leisure activity patterns of a sample (595) of countryside visitors in the Hull area. Details of individuals' activities, use of time, companions and perception of pursuits as “work” or “leisure” were obtained from time budget diaries.
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Glyptis S. A. (1981) Leisure life-styles, Reg. Studies 15, 311–326. This paper examines the life-styles and leisure activity patterns of a sample (595) of countryside visitors in the Hull area. Details of individuals' activities, use of time, companions and perception of pursuits as “work” or “leisure” were obtained from time budget diaries.
openaire +1 more source