Results 161 to 170 of about 1,604,294 (308)

Evolution of Space-Based Plant Growth Technologies for Hybrid Life Support Systems

, 2017
Robert Morrow, Orbital Technologies Corporation (ORBITEC), USAJohn Wetzel, Orbital Technologies Corporation (ORBITEC), USARobert Richter, Orbital Technologies Corporation (ORBITEC), USAThomas Crabb, Orbital Technologies Corporation (ORBITEC), USAICES500:
Morrow, Robert, Richter, Robert, Crabb, Thomas, Wetzel, John   +3 more
core  

Primary Stress Factors and Adaptive Mechanisms of Microalgae in Space Environments and Their Applications in Space Life Support Systems. [PDF]

Plants (Basel)
Dai S, Feng W, Lae J, Yu X, Ho CM, Yang F, Miao Q, Duan P.   +7 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Second Conference on Portable Life Support Systems

, 1972
Conference on portable life support systems for human ...

core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

1991 NASA Life Support Systems Analysis workshop

, 1992
The 1991 Life Support Systems Analysis Workshop was sponsored by NASA Headquarters' Office of Aeronautics and Space Technology (OAST) to foster communication among NASA, industrial, and academic specialists, and to integrate their inputs and disseminate ...
Evanich, Peggy L., Crabb, Thomas M., Gartrell, Charles F.   +2 more
core  

Micro/Nano-Reconfigurable Robots for Intelligent Carbon Management in Confined-Space Life-Support Systems. [PDF]

Nanomicro Lett
Lu W, Chen R, Zhan L, Xiang Q, Huang R, Wang L, Wang S, He H.   +7 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Critical investments in bioregenerative life support systems for bioastronautics and sustainable lunar exploration. [PDF]

NPJ Microgravity
Marshall Porterfield D, Tulodziecki D, Wheeler R, Davis Cross MK, Monje O, Rothschild LJ, Barker RJ, Schwertz H, Collicott S, Dutta S.   +9 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source