Results 101 to 110 of about 14,125,984 (386)

Aging as a consequence of misrepair -- A novel theory of aging [PDF]

, 2009
It is now increasingly realized that the underlying mechanisms which govern aging is a complex interplay of genetic regulation and damage accumulation. Aging as a result of accumulation of ‘faults’ on cellular and molecular levels, has been
Arne Wunderlin, Jicun Wang, Ravi Mahadeva, Thomas Michelitsch   +3 more
core   +4 more sources

Acarbose improves health and lifespan in aging HET3 mice

Aging Cell, 2019
To follow‐up on our previous report that acarbose (ACA), a drug that blocks postprandial glucose spikes, increases mouse lifespan, we studied ACA at three doses: 400, 1,000 (the original dose), and 2,500 ppm, using genetically heterogeneous mice at three
D. Harrison, R. Strong, S. Alavez, C. M. Astle, J. DiGiovanni, Elizabeth Fernandez, K. Flurkey, M. Garratt, J. Gelfond, M. Javors, M. Levi, G. Lithgow, F. Macchiarini, James F. Nelson, Stacey J Sukoff Rizzo, T. Slaga, T. Stearns, J. Wilkinson, Richard A. Miller   +18 more
semanticscholar   +1 more source

Adult Education Confronting White Christian Nationalism: A Thematic Analysis

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT As a way to conclude, this article elaborates key themes that emerged from the collected articles in this volume. Each article carries its own important message about the role of adult education in confronting White Christian nationalism, while here, Prins and Carr‐Chellman offer a thematic interpretation of the volume as a whole. These themes
Esther Prins, Davin Carr‐Chellman
wiley   +1 more source

Human development [PDF]

, 2011
This article draws attention to commonalities in the use of the term development in relation to global development as practised by the United Nations Development Programme, and human development as taught in foundation courses for teacher education ...
Drewery, Wendy
core   +2 more sources

The burden of intracranial atherosclerosis on cerebral small vessel disease: A community cohort study

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Exploring the prevalence and association between intracranial atherosclerosis (ICAS) and cerebral small vessel diseases (CSVD), this study delved beyond the current scope, utilising high‐resolution vessel wall MRI (HRVW‐MRI) to investigate how subtle changes in intracranial atherosclerotic features influence the various burdens of ...
Joseph Amihere Ackah, Heng Du, Wenjie Yang, Huixing Zeng, Jason Tsz Lok Chan, Michael Lung Cheung Lo, Xiangyan Chen   +6 more
wiley   +1 more source

Research on Life Extension of Primary Rubber Springs for Railway Vehicles

机车电传动, 2021
In order to understand and master the real change after the operation of a lifespan (5 years or 600,000 km) of the primary conical rubber spring, which is a critical part for railway vehicles, and to provide data support for life extension research and ...
Yunjie FAN, Yuxiang ZHANG, Haiming TAN, Zhiguo LI, Jun LUO, Zhongsan JIANG   +5 more
doaj  

Modulated Expression of the Protein Kinase GSK3 in Motor and Dopaminergic Neurons Increases Female Lifespan in Drosophila melanogaster

Frontiers in Genetics, 2020
Most eukaryotic genes express multiple transcripts and proteins, and a sophisticated gene expression strategy plays a crucial role in ensuring the cell-specificity of genetic information and the correctness of phenotypes. The Drosophila melanogaster gene
Mikhail V. Trostnikov, Ekaterina R. Veselkina, Anna V. Krementsova, Anna V. Krementsova, Stepan V. Boldyrev, Stepan V. Boldyrev, Natalia V. Roshina, Natalia V. Roshina, Elena G. Pasyukova   +8 more
doaj   +1 more source

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy. [PDF]

, 2019
Aging is characterized by the progressive loss of physiological function in all organisms. Remarkably, the aging process can be modulated by environmental modifications, including diet and small molecules.
Andersen, Julie, Butler, Victoria J, Chamoli, Manish, Jung, Manfred, Kao, Aimee W, Ng, Che-Ping, Simon, Roman P, Tezil, Tugsan, Verdin, Eric   +8 more
core  

Management and Outcomes in Confirmed or Suspected Acute Symptomatic Seizure: Role of Structured Outpatient Care

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Post‐discharge management and outcomes of acute symptomatic seizures (ASyS) remain underexplored. We analyzed post‐discharge ASM management and outcomes in ASyS patients undergoing continuous EEG (cEEG), including the role of outpatient care through a post‐acute symptomatic seizure (PASS) clinic. Methods We performed a single‐center,
Vineet Punia, MarieElena Byrnes, Nicolas R. Thompson, Neishay Ayub, Clio Rubinos, Sahar Zafar, Adithya Sivaraju, Zhong Ying, Jessica R. Fesler, Stephen Hantus, Post‐Acute Symptomatic Seizure Investigation and Outcomes Network (PASSION) investigators   +10 more
wiley   +1 more source

ADAPT NXT: Fixed Cycles or Every‐Other‐Week IV Efgartigimod in Generalized Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This phase 3b, open‐label, randomized ADAPT NXT study investigated the efficacy, safety, and tolerability of efgartigimod administered in either a fixed cycles dosing regimen (3 cycles of 4 once‐weekly infusions, with 4 weeks between cycles) or a cycle followed by every‐other‐week (Q2W) dosing.
Ali A. Habib, Kristl G. Claeys, Vera Bril, Yessar Hussain, Kelly Gwathmey, Gregory Sahagian, Elena Cortés‐Vicente, Edward Brauer, Deborah Gelinas, Anne Sumbul, Rosa H. Jimenez, Daniela Hristova, Delphine Masschaele, Renato Mantegazza, Andreas Meisel, Shahram Attarian, On behalf of the ADAPT NXT Study Group   +16 more
wiley   +1 more source