Results 111 to 120 of about 14,125,984 (386)
Fundamental equations linking methylation dynamics to maximum lifespan in mammals
Nature CommunicationsWe describe a framework that addresses concern that the rate of change in any aging biomarker displays a trivial inverse relation with maximum lifespan. We apply this framework to methylation data from the Mammalian Methylation Consortium.
Steve Horvath +4 more
doaj +1 more source
Is there a cap on longevity? A statistical review [PDF]
arXiv, 2021 There is sustained and widespread interest in understanding the limit, if any, to the human lifespan. Apart from its intrinsic and biological interest, changes in survival in old age have implications for the sustainability of social security systems. A central question is whether the endpoint of the underlying lifetime distribution is finite.
arxiv
Views on ageing: a lifespan perspective
European Journal of Ageing, 2019 Views on ageing (VoA) have special relevance for the ageing process by influencing health, well-being, and longevity. Although VoA form early in life, so far, most research has concentrated on how VoA affect later middle-aged and older adults.
A. Kornadt +5 more
semanticscholar +1 more source
Bone Marrow, Thymus and Blood: Changes Across the Lifespan [PDF]
Aging Health, 2009 The aim of this review is to present age-related changes in the bone marrow and thymus and their effects in later life. Age-related hematologic changes are marked by a decline in marrow cellularity, increased risk of myeloproliferative disorders and anemia, and a decline in adaptive immunity.
Mamatha Prabhakar +2 more
openaire +2 more sources
A PANoptosis‐Based Signature for Survival and Immune Predication in Glioblastoma Multiforme
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PANoptosis is a concept of total cell death characterized by pyroptosis, apoptosis, and necroptosis. We aimed to explore the clinical significance of PANoptosis‐related genes (PARGs) in glioblastoma multiforme (GBM). Methods Expression profiles of GBM were downloaded from the XENA database as a training dataset to construct a ...
Jun Yang +4 more
wiley +1 more source
Observed lifespan differential - global trends, policy impact and computational methods [PDF]
arXiv, 2018 The issue of longevity has been long time recognized as one of key concepts in demography. A particular aspect of longevity addressed in this paper is the difference in average observed duration of life for female and male population, called observed lifespan differential.
arxiv
A stochastic model of cell proliferation and death across a sequence of compartments [PDF]
arXiv, 2021 Cells of the human body have nearly identical genome but exhibit very different phenotypes that allow them to carry out specific functions and react to changes in their surrounding environment. This division of labour is achieved by cellular division and cellular differentiation, events which lead to a population of cells with unique characteristics ...
arxiv
Evaluating system change options and timing using the epoch syncopation framework [PDF]
, 2012 Complex engineering systems face many unknowns with respect to their operating contexts and time-varying stakeholder needs over their lifespan. A useful means for partitioning this problem is to consider a set of static snapshots of contexts with ...
Fulcoly, Daniel O. +2 more
core +1 more source
Changes in REM-Sleep Percentage Over the Adult Lifespan [PDF]
Sleep, 2007 To resolve inconsistencies in previously reported changes in percentage of rapid eye movement sleep (REM%) over the adult lifespan and to identify gaps in available information about adults' REM sleep.A research synthesis approach specifically designed to detect nonlinear change.
Elizabeth S. Jenuwine +3 more
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives To investigate whether pulse pressure or mean arterial pressure mediates the relationship between age and white matter hyperintensity load and to examine the mediating effect of white matter hyperintensities on cognition. Methods Demographic information, blood pressure, current medication lists, and Montreal Cognitive Assessment ...
Jade Hannan +8 more
wiley +1 more source