Results 11 to 20 of about 461,249 (325)

Topological turning points across the human lifespan [PDF]

Nature Communications
Structural topology develops non-linearly across the lifespan and is strongly related to cognitive trajectories. We gathered diffusion imaging from datasets with a collective age range of zero to 90 years old (N = 4,216).
Alexa Mousley, Richard A. I. Bethlehem, Fang-Cheng Yeh, Duncan E. Astle   +3 more
doaj   +2 more sources

Imeglimin may affect hemoglobin A1c accuracy via prolongation of erythrocyte lifespan in patients with type 2 diabetes mellitus: insights from the INFINITY clinical trial [PDF]

Frontiers in Endocrinology
BackgroundImeglimin is a novel type 2 diabetes (T2D) drug that is expected to improve mitochondrial function. In phase 3 trials, imeglimin demonstrated a gradual reduction in hemoglobin A1c (HbA1c), with a plateau at approximately 20–24 weeks.
Takeshi Osonoi, Shinichiro Shirabe, Miyoko Saito, Mitsuru Hosoya, Norie Watahiki, Nana Shiozawa, Satako Douguchi, Kensuke Ofuchi, Makoto Katoh, Makoto Katoh   +9 more
doaj   +2 more sources

Change and Stability in Political Ideology and Engagement over the Lifespan: A Retrospective Study [PDF]

Innov Aging
Kyla Prussman, Elizabeth Hahn Rickenbach, Jennifer C. Lucas, Kevin Doran   +3 more
openalex   +2 more sources

Measuring Change in Somatosensation Across the Lifespan [PDF]

The American Journal of Occupational Therapy, 2015
Abstract OBJECTIVE. The study aim was to determine natural variability in somatosensation across age groups using brief measures. We validated measures in a community-dwelling population as part of the National Institutes of Health (NIH) Toolbox for Assessment of Neurological and Behavioral Function (NIH Toolbox; http://www.nihtoolbox ...
Dunn, W., Griffith, J. W., Sabata, D., Morrison, M. T., MacDermid, J. C., Darragh, A., Schaaf, R., Dudgeon, B., Connor, L. T., Carey, Leeanne., Tanquary, J.   +10 more
openaire   +4 more sources

A naturally occurring polymorphism at Drosophila melanogaster Lim3 Locus, a homolog of human LHX3/4, affects Lim3 transcription and fly lifespan. [PDF]

PLoS ONE, 2010
Lim3 encodes an RNA polymerase II transcription factor with a key role in neuron specification. It was also identified as a candidate gene that affects lifespan.
Olga Yu Rybina, Elena G Pasyukova
doaj   +1 more source

Goin’ Home: The Role of Vowel Raising in Indexing an Ethnic Identity

Lifespans and Styles, 2017
Vowel height can be seen as a feature indexing a particular ethnic identity or indicating a style shift between two such identities. This paper focuses on Bradford-born South Asian musician Zayn Malik, an interesting subject given his prominent status as
Suzey Ingold
doaj   +1 more source

Variable pathogenicity determines individual lifespan in Caenorhabditis elegans. [PDF]

PLoS Genetics, 2011
A common property of aging in all animals is that chronologically and genetically identical individuals age at different rates. To unveil mechanisms that influence aging variability, we identified markers of remaining lifespan for Caenorhabditis elegans.
Adolfo Sánchez-Blanco, Stuart K Kim
doaj   +1 more source

Perturbing the community grammar: Individual differences and community-level constraints on sociolinguistic variation

Glossa, 2019
The traditional focus of variationist sociolinguistic research is the patterning of language variation at the level of the community, which individual language users are said to learn and reproduce (Labov 1972; 2012).
Laurel MacKenzie
doaj   +2 more sources

Perturbation of NAD(P)H metabolism with the Lb NOX xenotopic tool extends lifespan and mitigates age-related changes [PDF]

Sci Adv
Shweta Yadav, Xingxiu Pan, Shengxi Li, Peter Martin, Ngoc Hoang, Kejin Chen, Aditi Karhadkar, Jatin Malhotra, Austin L. Zuckerman, Subrata Munan, Markus K. Klose, Lin Wang, Valentin Cracan, Andrey A. Parkhitko   +13 more
openalex   +2 more sources

Aging in vitro and D-glucose uptake kinetics of diploid human fibroblasts [PDF]

, 1981
By use of a rapid technique, initial rates of D-glucose transport were obtained during the lifespan in vitro of a commercially available strain of human embryo lung fibroblasts (Flow 2000).
Aizawa, Berumen, Blomquist, Bowman, Bramwell, Cremer, Cristofalo, Cristofalo, Germinario, Goldstein, Grinna, Harley, Haslam, Hayflick, Hayflick, Heldt, Hirschberg, Kaplan, Kelley, Klingenberg, Lowry, Martin, Martin, McKerrow, Plagemann, Plagemann, Polgar, Roberts, Rothstein, Schachtschabel, Schneider, Schneider, Schneider, Simons, Smith, Smith, Stevenson, Werdan, Zs.-Nagy   +38 more
core   +1 more source