Results 51 to 60 of about 2,160,498 (281)

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

Epithelial SLC25A20 Deficiency Drives Immunosuppressive Neutrophil Remodeling via ARG1 Palmitoylation to Promote Colorectal Cancer

Advanced Science, EarlyView.
SLC25A20 deficiency in tumor cells compromises mitochondrial LCFA transport, which suppresses FAO and drives compensatory release of palmitic acid‐enriched lipids into the TME. These tumor‐derived palmitic acids are taken up by TANs, promoting ZDHHC18‐catalyzed ARG1 palmitoylation.
Yue Han, Tian‐Yuan Tan, Bin Zhang, Ye‐Bin Fu, Wen Chen, Min‐Hui Yang, Yi‐Qing Wang, Yan‐Qing Ding, Shuang Wang   +8 more
wiley   +1 more source

Liveaboards in the Mediterranean: Luxury or Marginality? – Ethnographic Refl ections on Maritime Lifestyle Migrations

Dve Domovini, 2012
As a result of the opening of internal borders in the EU and the rapid development of affordable navigation technology, there is a constantly increasing number of people from Western Europe in the Mediterranean who have adopted a lifestyle that revolves ...
Nataša Rogelja
doaj  

On migration, geography, and epistemic communities

Comparative Migration Studies, 2020
This commentary paper starts by questioning the assumption that migration means international migration, and goes on to affirm that migration studies has indeed come of age as a coherent if highly diverse research field.
Russell King
doaj   +1 more source

Internet use and adolescent development: A conceptual model integrating behavioral and contextual theories

American Journal of Community Psychology, EarlyView.
Abstract In the digital era, adolescent development is deeply embedded in the cyber environment. Despite ongoing debate on the benefits and/or risks that Internet use brings to adolescents in empirical studies, conceptual and theoretical discussion on the influences of the intensity and modalities of Internet use is peripheral.
Linxiao Zhang, Lin Fang, Faye Mishna, Liangqi Shen   +3 more
wiley   +1 more source

Owning Home, Finding Belonging: Relational Meanings of Homeownership for Migrant Healthcare Workers in Australia

Australian Journal of Social Issues, EarlyView.
ABSTRACT Migrant healthcare workers in Australia find themselves at the centre of three intersecting concerns, often presented as ‘crises’ in contemporary discourse: the ‘care crisis’, the ‘housing crisis’ and the ‘migration crisis.’ Yet their own perspectives on these issues are rarely foregrounded. This paper explores the role of homeownership in the
Leah Williams Veazey
wiley   +1 more source

Australian Activists as Storytellers in Digital Spaces: Acquiring Skills, Producing Content and Getting the Message Out

Australian Journal of Social Issues, EarlyView.
ABSTRACT As modes of activism rapidly evolve, activists—both seasoned and emerging—must increasingly navigate a hybrid terrain of both digital and non‐digital engagement. This paper draws on the personal narratives of 16 nascent activists based in Australia to explore how they develop competencies related to digital storytelling, which is critical to ...
Garth Stahl, Miri Yemini, Claire Maxwell, Yating Hu, Benjamin Adams, Sarah Bergen   +5 more
wiley   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Lifestyle Mobilities: The Crossroads of Travel, Leisure and Migration

Mobilities, 2013
This article examines how the mobilities paradigm intersects with physically moving as an ongoing lifestyle choice. We conceptualise a lens of ‘lifestyle mobilities’ that challenges discrete notions of and allows for a wider grasp of the increasing fluidity between travel, leisure and migration.
Cohen, Scott, Duncan, T, Thulemark, M
openaire   +4 more sources

Reconceptualising ‘agency in mobility’: Agency for becoming and other forms of agency in study abroad

British Educational Research Journal, EarlyView.
Abstract Study‐abroad programs are increasingly adopted and supported by institutions and governments as a strategic tool for deepening internationalisation and public diplomacy through people‐to‐people, institution‐to‐institution and country‐to‐country connections.
Ly Thi Tran, Thinh Huynh
wiley   +1 more source