Results 61 to 70 of about 6,172,268 (319)

Failure Analysis of Resistance Spot-Welded Structure Using XFEM: Lifetime Assessment

Applied Sciences, 2023
Due to their effective and affordable joining capabilities, resistance spot-welded (RSW) structures are widely used in many industries, including the automotive, aerospace, and manufacturing sectors.
Murat Demiral, Ertugrul Tolga Duran
doaj   +1 more source

Use of groundwater lifetime expectancy for the performance assessment of a deep geologic waste repository: 1. Theory, illustrations, and implications

, 2011
Long-term solutions for the disposal of toxic wastes usually involve isolation of the wastes in a deep subsurface geologic environment. In the case of spent nuclear fuel, if radionuclide leakage occurs from the engineered barrier, the geological medium ...
Andrićevic, Arnold, Bear, Birdsell, Cornaton, Cornaton, Cornaton, Dagan, Dagan, Dagan, Danckwerts, E. A. Sudicky, F. J. Cornaton, Garabedian, Gardiner, Ginn, Goode, J. F. Sykes, Jury, Jury, Kolmogorov, LaBolle, Langevin, Maxwell, National Research Council (NRC), Neupauer, Park, Pohlmann, Rubin, S. D. Normani, Selroos, Shapiro, Spivakovskaya, Sudicky, The Council of European Union, Therrien, Tóth, Uffink, Van Kooten, Varni, Walker, Weissmann, Y.-J. Park   +42 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Lifetime assessment for an ideal elastoplastic thick-walled spherical member under general mechanochemical corrosion conditions [PDF]

, 2013
The problem of the equal-rate mechanochemical wear of an elastic-perfectly plastic thick-walled spherical shell under internal and external pressure is solved analytically.
Pronina, Yulia G.
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Heat Exchanger Network Synthesis Considering Risk Assessment for Entire Network Lifetime

Chemical Engineering Transactions, 2017
Considering risk assessment at the early-stage of Heat Exchanger Network (HEN) synthesis can significantly contribute to obtaining inherently safer design.
A. Nemet, J.J. Klemes, Z. Kravanja
doaj   +1 more source

Assessment of lethality and its clinical correlates in suicide attempters with mood disorders

Industrial Psychiatry Journal, 2022
Background: Relatively limited literature is available on lethality assessment for suicide attempts in affective disorders from the Indian subcontinent.
Nishtha Chawla, Raman Deep, Snehil Gupta, Anuranjan Vishwakarma, Mahadev S Sen   +4 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source