Results 141 to 150 of about 126,704 (292)

Results of breast cancer risk assessment and hereditary cancer genetic testing in community obstetrics and gynaecology practice following a prospective quality Improvement initiative

Journal of Obstetrics and Gynaecology
Background Clinical guidelines recommend hereditary cancer risk assessment (HCRA) to identify candidates for genetic counselling and testing based on personal and family history.
Richard Waldman, Mark DeFrancesco, John Feltz, Daniel Welling, Wade Neiman, Edith Smith, Logan Schneider, Lauren Lenz, Katherine Johansen Taber, Royce Adkins   +9 more
doaj   +1 more source

Cancer incidence in relatives of British Fanconi Anaemia patients.

, 2008
BACKGROUND: Fanconi anemia (FA) is an autosomal recessive DNA repair disorder with affected individuals having a high risk of developing acute myeloid leukaemia and certain solid tumours. Thirteen complementation groups have been identified and the genes
Ball Jan, Mathew, CG, Tischkowitz, Marc, Hodgson, SV, Hodgson Shirley V, Tischkowitz Marc, Easton, DF, Ball, J, Mathew Christopher G, Mathew, Christopher G.; id_orcid, Tischkowitz, M, Easton Douglas F, Ball, Jan, Hodgson, Shirley V., Easton, Douglas F.   +14 more
core   +1 more source

Sleep Disturbances in Adults With Tuberous Sclerosis Complex: Influences of Treatment and Clinical Features

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Tuberous sclerosis complex (TSC) is a genetic condition with multisystem neurocutaneous signs, including hamartomas, epilepsy, and neuropsychological difficulties. Although sleep disorders are increasingly recognized in TSC, they remain poorly described in adults.
Kirstin A. Risgaard, Laura Farach, Hope Northrup, Sarah L. Wilson, Deborah Pearson, Syed Hashmi, Kate Richardson   +6 more
wiley   +1 more source

Breast cancer risk assessment: Calculating lifetime risk using the Tyrer-Cuzick Model

, 2016
One size does not fit all for breast cancer screening. Early detection and prevention are most effective for those most at risk. Several United States organizations recommend offering annual screening breast magnetic resonance imaging in addition to ...
Himes, Deborah O., PhD, APRN-BC, Luthy, Beth E., Root, Aubri E., Gammon, Amanda   +3 more
core   +2 more sources

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Projecting individualized probabilities of lifetime all-cancer risk

Abstract Introduction Technological advances and direct-to-consumer marketing have unearthed significant organic demand from patients for cancer screening and prevention. However, in the absence of strong data or guidelines, physicians have minimal support on how to approach patients in clinical ...
Neel M. Butala, Noor Al-Hammadi, Asiri Ediriwickrema, Jaime L. Schneider, Aaron Fullerton, Jeya Balasubramanian, Parichoy Pal Choudhury, Nilanjan Chatterjee   +7 more
openaire   +2 more sources

The HCMV‐encoded miR‐UL36‐3p promotes angiogenesis of endothelial cells by downregulating FOXO3

Animal Models and Experimental Medicine, EarlyView.
This illustration shows the role of hcmv‐miR‐UL36‐3p in endothelial cell angiogenesis. During productive infection, endothelial cells express HCMV‐encoded miRNAs. Viral hcmv‐miR‐UL36‐3p promotes endothelial cell proliferation, migration, and capillary tube formation by directly targeting and downregulating FOXO3. The pro‐angiogenic activity of hcmv‐miR‐
Chen Wang, Mengyu Li, Guosheng Li, Hao Zhang, Cheng Wang, Chen‐Yu Zhang   +5 more
wiley   +1 more source

Lesion-mimicking DIXON swap artifact in contrast-enhanced subtraction breast MRI

Radiology Case Reports
Breast cancer is the most common cancer in women; approximately 1 in 8 women is diagnosed with breast cancer in their lifetime. Some women are at significantly higher risk of developing breast cancer, including women carrying mutations in the BRCA1/2 ...
Sebastian Bickelhaupt, MD, Frederik Bernd Laun, PhD, Michael Uder, MD, Sabine Ohlmeyer, MD   +3 more
doaj   +1 more source

Excess lifetime cancer mortality risk attributable to radiation exposure from computed tomography examinations in children

, 2007
The use of computed tomography in Israel has been growing rapidly during recent decades. The major drawback of this important technology is the exposure to ionizing radiation, especially among children who have increased organ radiosensitivity and a long
Ron, Elaine, Shalev, Varda, Chodick, Gabriel, Ronckers, Cécile M.   +3 more
core  

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source