Results 241 to 250 of about 126,704 (292)

Re-evaluating hereditary breast and ovarian cancer risk: clinical impact of updated multigene panel sequencing and genetic counseling. [PDF]

Fam Cancer
Gislinge JIP, Byrjalsen A, Naver KV, Clausen HV, Ravn P, Petersen KR, Wadt KAW.   +6 more
europepmc   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Should Sickle Cell Disease Be Considered a Cancer Predisposition Syndrome? [PDF]

Children (Basel)
Casadessus E, Pastore Y, Pincez T.
europepmc   +1 more source

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

Lifetime Drinking Patterns Shape Awareness of Alcohol-Related Chronic Disease Risks in U.S. Adults: Findings from the National Alcohol Survey. [PDF]

J Stud Alcohol Drugs
Martinez-Matyszczyk P, Cook WK, Kerr WC.
europepmc   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

Etiology and risk factors for lung cancer in female Asian never smokers: a systematic review. [PDF]

Ther Adv Med Oncol
Guha S, Levine K, Liang E, Baskin AS, Ou M, Velotta JB.   +5 more
europepmc   +1 more source

Adverse Childhood Experiences and Substance Use: The Mediating Role of Executive Function Deficits

Journal of Adolescence, EarlyView.
ABSTRACT Introduction While adverse childhood experiences (ACEs) are robust risk factors for adolescent substance use, the prospective neurocognitive pathways linking both cumulative and specific adversities to substance use remain understudied. This study tested a vulnerability model by examining whether executive function (EF) deficits mediate the ...
Mahsa P. Yousefkhani, Xiafei Wang, Sara A. Vasilenko   +2 more
wiley   +1 more source

Socioeconomic inequalities and dynamic changes in sex differences in lifetime risks of peptic ulcer disease. [PDF]

Biol Sex Differ
Shi D, Li Y, Zheng R, Wang S, Chen R.
europepmc   +1 more source

Association between night shift work, genetic risk, and chronic kidney disease: a prospective cohort study based on the UK Biobank. [PDF]

Front Public Health
Xu Q, Fan J, Chen Z, Lv D, Zhou D, Shou Z, Xie X.   +6 more
europepmc   +1 more source