Results 71 to 80 of about 126,704 (292)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Alcohol consumption and the risk for prostate cancer in the European Prospective Investigation into Cancer and Nutrition.

, 2008
Alcohol is a risk factor for several types of cancer. However, the results for prostate cancer have been inconsistent, with most studies showing no association. Within the European Prospective Investigation into Cancer and Nutrition, detailed information
Tjonneland, Anne, Bingham, Sheila, Ferrari, Pietro, González, Carlos A., Key, Timothy, Hallmans, Göran, Bergmann, Manuela M., González, CA, Jensen, Majken K., Palli, D, Naska, A, Jensen, Majken K, Khaw, Key-Tee, Tjønneland, A, Johnsen, Nina Fons, Johnsen, NF, Bueno-de-Mesquita, H Bas, Barricarte, Aurelio, Key, Timothy J., Trichopoulou, Antonia, Palli, Domenico, Martinez-Garcia, Carmen, Riboli, Elio, Jenab, Mazda, Tumino, Rosario, Navarro, C, Rohrmann, Sabine, Trichopoulos, D, Naska, Androniki, Bueno-de-Mesquita, H. Bas, Bergmann, Manuela M, Quiros, J Ramon, Wirfält, Elisabet, Key, Timothy J, Sacerdote, Carlotta, Linseisen, Jakob, Lund University., Kaaks, Rudolf, Larrañaga, N, Egevad, Lars, Manjer, Jonas, Pala, V, Barricarte, A, Weikert, Cornelia, Stattin, Pär, Vrieling, Alina, Trichopoulos, Dimitrios, Quiros, J. Ramon, Martínez-García, C, Linseisen, J, Wirfält, Elisabet,, Overvad, Kim, Gonzalez, Carlos A, Overvad, K, Vrieling, A, Sacerdote, C, Tjønneland, Anne, Navarro, Carmen, Trichopoulou, A, Larranaga, Nerea, Tumino, R, Johnsen, Nina Føns, Quiros, JR, Pala, Valeria, Kaaks, R, Bergmann, MM, Weikert, C, Rohrmann, S, Jensen, MK, Bueno-de-Mesquita, HB   +69 more
core   +1 more source

Lifetime alcohol intake is associated with an increased risk of KRAS+ and BRAF-/KRAS- but not BRAF+ colorectal cancer. [PDF]

, 2016
Ethanol in alcoholic beverages is a causative agent for colorectal cancer. Colorectal cancer is a biologically heterogeneous disease, and molecular subtypes defined by the presence of somatic mutations in BRAF and KRAS are known to exist.
Jayasekara, Harindra, Hodge, Allison M., Giles, Graham G., Jenkins, Mark A., Hopper, John L., Williamson, Elizabeth J., English, Dallas R., Williamson, Elizabeth J, Buchanan, Daniel D., Buchanan, Daniel D, Walters, Rhiannon, Milne, Roger L., Clendenning, Mark, Southey, Melissa C, Jenkins, Mark A, Milne, Roger L, English, Dallas R, Hodge, Allison M, Hopper, John L, Giles, Graham G, MacInnis, Robert J, Room, Robin,, Room, Robin, Southey, Melissa C., Rosty, Christophe, MacInnis, Robert J.   +25 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Assessing spatio-temporal variability of risk surfaces using residential history data in a case control study of breast cancer

International Journal of Health Geographics, 2005
Background Most analyses of spatial clustering of disease have been based on either residence at the time of diagnosis or current residence. An underlying assumption in these analyses is that residence can be used as a proxy for environmental exposure ...
Vena John E, Nie Jing, Bonner Matthew R, Rogerson Peter A, Han Daikwon, Muti Paola, Trevisan Maurizio, Freudenheim Jo L   +7 more
doaj   +1 more source

Lifetime alcohol consumption and upper aero-digestive tract cancer risk in the Melbourne Collaborative Cohort Study

, 2015
Cohort studies have rarely examined the association between upper aero-digestive tract (UADT) cancer risk and lifetime alcohol intake. We examined the associations between incident squamous cell carcinoma of the UADT (oral cavity, pharynx, larynx, and ...
Jayasekara, Harindra, Hodge, Allison M., Giles, Graham G., Hopper, John L., English, Dallas R., MacInnis, Robert J., Room, Robin,   +6 more
core   +1 more source

Alcohol intake and risk of colorectal cancer: results from the UK Dietary Cohort Consortium. [PDF]

, 2010
BACKGROUND: Epidemiological studies have suggested that excessive alcohol intake increases colorectal cancer (CRC) risk. However, findings regarding tumour subsites and sex differences have been inconsistent.
Khaw, K-T, Keogh, R. H., Park, J. Y., R H Keogh, Greenwood, DC, Burley, V. J., D Kuh, Rodwell, SA, Kuh, D., R N Luben, A A Mulligan, Fentiman, I. S., Fentiman, Ian, Dahm, C. C., Mishra, GD, I R White, Shipley, MJ, Shipley, M. J., Mishra, G. D., J Y Park, Cade, J. E., M J Shipley, Brunner, E. J., Luben, RN, Cairns, Benjamin, Dahm, CC, K-T Khaw, Rodwell, S. A., Stephen, AM, S A Rodwell, Mitrou, PN, Burley, VJ, Fentiman, IS, Khaw, K. T., P N Mitrou, Greenwood, D. C., Keogh, RH, Luben, R. N., E J Brunner, Cairns, BJ, Mulligan, AA, Mitrou, P. N., Park, JY, Spencer, Elizabeth, I S Fentiman, D C Greenwood, B J Cairns, Cade, JE, Brunner, EJ, V J Burley, Stephen, A. M., White, IR, A M Stephen, Mulligan, A. A., Kuh, D, E A Spencer, J E Cade, C C Dahm, G D Mishra, Cairns, B. J., Spencer, E. A., Khaw, KT, White, I. R., Spencer, EA   +63 more
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Genetic testing and risk interpretation: How do women understand lifetime risk results?

Judgment and Decision Making, 2010
Genetic screening for BRCA1 and BRCA2 gives women the opportunity for early detection, surveillance, and intervention. One key feature of genetic testing and counseling is the provision of personal lifetime risk.
Yaniv Hanoch, Talya Miron-Shatz, Mary Himmelstein   +2 more
doaj   +1 more source

Population Distribution of Lifetime Risk of Ovarian Cancer in the United States [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2015
Abstract Background: In U.S. women, lifetime risk of ovarian cancer is 1.37%, but some women are at a substantially lower or higher risk than this average. Methods: We have characterized the distribution of lifetime risk in the general population. Published data on the relative risks and their variances for five well-
Celeste Leigh, Pearce, Daniel O, Stram, Roberta B, Ness, Douglas A, Stram, Lynda D, Roman, Claire, Templeman, Alice W, Lee, Usha, Menon, Peter A, Fasching, Jessica N, McAlpine, Jennifer A, Doherty, Francesmary, Modugno, Joellen M, Schildkraut, Mary Anne, Rossing, David G, Huntsman, Anna H, Wu, Andrew, Berchuck, Malcolm C, Pike, Paul D P, Pharoah   +18 more
openaire   +2 more sources