Results 51 to 60 of about 17,125 (245)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Effects of airfoil geometry on high-speed aerodynamic characteristics of high-pressure capturing wing configuration

Kongqi donglixue xuebao
The aerodynamic performance of the high-pressure capturing wing (HCW), a novel aerodynamic configuration with significant promise for high-speed aircraft, primarily depends on its geometry and positioning.
Fengyi Wang, Siyuan Chang, Yao Xiao, Guangli Li, Zhongwei Tian, Kai Cui   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Numerical Simulation and Experimental Study on the Aerodynamics of Propulsive Wing for a Novel Electric Vertical Take-Off and Landing Aircraft

Aerospace
The electric vertical take-off and landing (eVTOL) aircraft offers the advantages of vertical take-off and landing, environmental cleanliness, and automated control, making it a crucial component of future urban air traffic.
Junjie Wang, Xinfeng Zhang, Jiaxin Lu, Zhengfei Tang   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

CFD analysis of aerodynamic correlation mechanism in ski jumping takeoff-flight

Kongqi donglixue xuebao
While previous studies have extensively examined how takeoff and flight techniques affect performance (e.g., jump distance) from a kinematic perspective, few have focused on aerodynamic dynamics, nor the intrinsic relationship between these two phases ...
Jinglun Yu, Jinglun Yu, Jin Yang, Shuo Qi, Shengnian Zhang, Yantao Lou   +5 more
doaj   +1 more source

The Influence of Ship Rolling Motion on Take-Off Aerodynamic Characteristics of Aircraft

Polish Maritime Research, 2018
Ship motion is an important factor affecting on the safety of ski-jump take-off. The simplified frigate ship SFS1 was numerically simulated, and the results were compared with the experimental data, the feasibility of the calculation method was verified;
Zheng He, Xiao-yu Sun, Xuan Gu
doaj   +1 more source