Results 151 to 160 of about 7,951,401 (343)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Evaluation of a New Energy Recycling Hydraulic Lift Cylinder for Forwarders
Croatian Journal of Forest Engineering, 2016 In mechanized forestry, much of the work is conducted by use of cranes, and recovering potential energy is a possible method to reduce energy consumption when using cranes for lift work.
Jussi Manner +3 more
doaj
Flow Control Applications [PDF]
Flow control has a long history with many successes across a plethora of applications. This report addresses the characteristics of the approaches that are actually used, why they are used, the many approaches that are not used, and why.
Bushnell, Dennis M., Wygnanski, Israel
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Enhanced Convex Lifting for Environment With Complex Shaped Obstacles
2025 29th International Conference on System Theory, Control and Computing (ICSTCC)In this paper, we revisit the path planning approach based on convex lifting and extend it to accommodate non-convex obstacles. Obstacles are modeled as overlapping unions of polyhedra. To handle complex environments, a preprocessing module is required to reconstruct the obstacles, and convex lifting is used to obtain an interconnected graph.
Zhao, Zhixin +4 more
openaire +2 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Graphene-enabled laser lift-off for ultrathin displays
Nature CommunicationsLaser lift-off (LLO) of ultrathin polyimide (PI) films is important in the manufacturing of ultrathin displays. However, conventional LLO technologies face challenges in separating the ultrathin PI films without causing mechanical and electrical damage ...
Sumin Kang +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Innovative Dual Rotor Wind Turbine Design Based on Humpback Whale Blades: Simulation Analysis
Energy Science & EngineeringTo enhance the performance of wind turbines, this study investigates the integration of two wind energy harvesting systems. An optimal wind turbine configuration has been identified by using dual rotor wind turbine (DRWT) technology with a novel blade ...
Mais Alzgool +2 more
doaj +1 more source