Results 41 to 50 of about 27,008 (268)

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Combined Intra‐ and Extra‐articular Reconstruction of the Anterior Cruciate Ligament: The Reconstruction of the Knee Anterolateral Ligament

Arthroscopy Techniques, 2015
Abstract We present a new technique for the combined intra‐ and extra‐articular reconstruction of the anterior cruciate ligament. Intra‐articular reconstruction is performed in an outside‐in manner according to the precepts of the anatomic femoral tunnel technique.
Camilo Partezani Helito, M.D., Marcelo Batista Bonadio, M.D., Riccardo Gomes Gobbi, M.D., Roberto Freire da Mota e Albuquerque, M.D., Ph.D., José Ricardo Pécora, M.D., Ph.D., Gilberto Luis Camanho, M.D., Ph.D., Marco Kawamura Demange, M.D., Ph.D.   +6 more
openaire   +3 more sources

Modified Arthroscopic Brostrom Procedure With Bone Tunnels

Arthroscopy Techniques, 2016
The open anatomic repair of the anterior talofibular and calcaneofibular ligaments (modified Brostrom procedure) is widely accepted as the standard surgical stabilization procedure for lateral ankle instability that does not respond to conservative ...
Tun Hing Lui, M.B.B.S.(H.K.), F.R.C.S.(Edin.), F.H.K.A.M., F.H.K.C.O.S.
doaj   +1 more source

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai, Zehui Lv, Chen Zhang, Xingdong Yang, Ruoying Wang, Yixin Bian, Jiawei Xu, Han Wang, Yingjie Wang, Long Bai, Jiacan Su, Xisheng Weng   +11 more
wiley   +1 more source

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

A novel arthroscopic classification of deltoid ligament injuries in ankle fractures and its impact on surgical management

Journal of the Foot & Ankle
Introduction: Ankle fractures have an annual incidence of 0.1%-0.2% and may be associated with deltoid ligament injury in up to 58% of cases. The true prevalence and severity of these lesions may be underestimated when assessed using indirect diagnostic
Roberto Zambelli de Almeida Pinto, Hugo Bertani Dressler, Miquel Dalmau Pastor, Daniel Soares Baumfeld, Rodrigo Simões Castilho, João Murilo Brandão Magalhães   +5 more
doaj   +1 more source

Clinical outcomes of arthroscopic and navigation-assisted two tunnel technique for coracoclavicular ligament augmentation of acute acromioclavicular joint dislocations

BMC Musculoskeletal Disorders, 2021
Background The purpose of this study was to present a navigated image-free augmentation technique for the acromioclavicular joint (ACJ) and coracoclavicular (CC) ligaments and to report the clinical and radiological outcomes.
Jan Theopold, Ralf Henkelmann, Claus Zhang, Tobias Schöbel, Georg Osterhoff, Pierre Hepp   +5 more
doaj   +1 more source

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin   +23 more
wiley   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

CT Arthrography of the Elbow: What Radiologists Should Know

Tomography
Computed tomography (CT) arthrography is a quickly available imaging modality to investigate elbow disorders. Its excellent spatial resolution enables the detection of subtle pathologic changes of intra-articular structures, which makes this technique ...
Gianluca Folco, Carmelo Messina, Salvatore Gitto, Stefano Fusco, Francesca Serpi, Andrea Zagarella, Mauro Battista Gallazzi, Paolo Arrigoni, Alberto Aliprandi, Marco Porta, Paolo Vitali, Luca Maria Sconfienza, Domenico Albano   +12 more
doaj   +1 more source