Results 201 to 210 of about 28,587,314 (277)

Protein Corona Engineering of Lipid Nanoparticles Enables Efficient Functional Gene Silencing in the Liver

Small, EarlyView.
By shaping the protein corona, lipid composition directs LNP tropism and enables the preferential delivery of a TIMP1‐targeting siRNA to liver macrophages. In a murine model of primary biliary cholangitis, this strategy promoted macrophage reprogramming and attenuated liver fibrosis.
Naths G. Sukubo, Serena Renzi, Martina B. Violatto, Leila Altigieri, Anna L. Capriotti, Andrea Cerrato, Aldo Laganà, Luca Digiacomo, Erica Quagliarini, Antonio Minopoli, Massimiliano Papi, Daniela Pozzi, Carlo A. Scirè, Pietro Invernizzi, Paolo Bigini, Giulio Caracciolo   +15 more
wiley   +1 more source

Optically Driven AuCu Alloying in Single Nanoparticles Revealed by In Situ TEM

Small, EarlyView.
In situ transmission electron microscopy with picosecond laser illumination reveals how single gold nanorods reversibly take up and release copper from their carbon support, forming homogeneous AuCu alloys. Laser fluence and illumination time serve as control parameters, making composition dynamically tunable, and with it the functional properties it ...
Francesca Scalerandi, Loriane Monin, Nathan J. Mowry, Wiebke Albrecht   +3 more
wiley   +1 more source

Machine Learning for Programmable Nanosystems: From Liposome Formulation to DNA Origami and Hybrid Vesicles

Small, EarlyView.
This mini review highlights how machine learning can accelerate the design of programmable nanosystems. It summarizes data‐driven approaches for predicting liposome properties, guiding DNA origami design and image analysis, and optimizing emerging liposome‐DNA hybrid platforms.
Daniel Q. Zhang, Matthew A. B. Baker
wiley   +1 more source

Design, synthesis and activity evaluation of tetrahydroisoquinoline‐based programmed cell death ligand 1 inhibitors

Smart Molecules, EarlyView.
Based on a 3D‐quantitative structure‐activity relationship pharmacophore model, structural optimization of Y6 yielded Y7f. Mechanistic studies revealed that Y7f acted as a programmed death receptor 1/programmed cell death ligand 1 (PD‐L1) interaction inhibitor by inducing PD‐L1 dimerization. Y7f restored T‐cell function.
Menglin Yu, Sen Cai, Yanyan Pan, Heshuang Wang, Fengwu Zhang, Aiyu Ma, Shixuan Lv, Xiuhan Guo, Shisheng Wang, Qiling Song, Chunyan Ma, Shuai Wang, Li Zhang, Jian Wang, Qingwei Meng, Yueqing Li   +15 more
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

How We Simulate Nanopores

Small Methods, EarlyView.
Nanopore technology has revolutionized single‐molecule sensing, yet it suffers from an inherent interpretive challenge. Molecular dynamics has emerged as a go‐to method for determining the relationship between the structure of translocating molecules and the nanopore current signals.
Behzad Mehrafrooz, Xavier Mleziva, Meng Xu, Melika Shekari, Christopher Maffeo, Aleksei Aksimentiev   +5 more
wiley   +1 more source

A 4D‐STEM Tomographic Framework Assisted by Object Tracking for Nanoparticle Structure Determination

Small Methods, EarlyView.
4D‐STEM tomography is used as a new methodology for 3D ED data acquisition to solve structures. Object tracking and segmentation methods are applied for the extraction of 3D ED datasets from regions of interest in a 4D‐STEM tomogram. Owing to its nanometric resolution, 4D‐STEM tomography can tackle challenging samples being too small for 3D ED, have ...
Saleh Gholam, Arno Annys, Irina Skvortsova, Erica Cordero Oyonarte, Amirhossein Hajizadeh, Philippe Boullay, Johan Hofkens, Johan Verbeeck, Joke Hadermann   +8 more
wiley   +1 more source

Microfluidic Molecular Diagnostic Chips: Functional Modules, Integration Strategies, and Emerging Applications

Small Methods, EarlyView.
This comprehensive review delivers an engineering‐centric analysis of microfluidic molecular diagnostic chips, breaking them down into foundational modules from fluid manipulation to bio‐sensing. Beyond chip design, it evaluates sample‐to‐answer integration strategies and commercial readiness levels.
Donghoon Koo, Egor Kokin, Sangyul Baik, Chanyong Park, Minji Kim, Jeongmin Kim, Ryungeun Song, Hosub Lim   +7 more
wiley   +1 more source

Synthesis and Pd(II) Complexes of an Unsymmetric and Flexible Ferrocene Bisphosphine

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
Insertion of flexible spacers into the pivotal C(ferrocene)P bonds in dppf increases flexibility of the resulting homologated ligands and lowers their tendency to coordinate as P,P′‐chelating ligands. To expand the family of flexible homologated analogs of 1,1′‐bis(diphenylphosphino)ferrocene, the unsymmetric bisphosphine 1‐(diphenylphosphino)‐1′‐[2 ...
Jakub Antala, Matěj Vlček, Ivana Císařová, Petr Štěpnička   +3 more
wiley   +1 more source

A versatile on‐axis visualization system for the macromolecular crystallography beamline BM07 at the ESRF

Journal of Synchrotron Radiation, EarlyView.
A compact on‐axis microscope installed on the endstation of the macromolecular crystallography beamline BM07 at the ESRF is described. The system combines dual‐magnification on‐axis sample visualization with on‐axis laser injection and fluorescence measurements in back‐scattering geometry.
Alexandre Appolaire, Philippe Jacquet, Lucas Petit, Eric Mathieu, Eric Girard, Sylvain Engilberge, Antoine Royant   +6 more
wiley   +1 more source