Results 121 to 130 of about 718,207 (427)
Isoprenaline increases Excursive Restitution Slope in the Conscious Rabbit with Ischaemic Heart Failure [PDF]
arXiv, 2009 Background: An increased QT/RR slope is hypothesized to be predictive of sudden cardiac death after myocardial infarction. Previous studies have shown that beta-adrenergic stimulation increases QT/RR slope, but the effects of beta-adrenergic stimulation on QT/RR slope in heart failure are unknown.
arxiv
Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor. [PDF]
, 2018 Cyclic STAT3 decoy (CS3D) is a second-generation, double-stranded oligodeoxynucleotide (ODN) that mimics a genomic response element for signal transducer and activator of transcription 3 (STAT3), an oncogenic transcription factor.
Grandis, Jennifer R +5 more
core +2 more sources
Chemical Protein Synthesis with the α-Ketoacid-Hydroxylamine Ligation.
Accounts of Chemical Research, 2017 The coupling of an α-ketoacid and a hydroxylamine (KAHA ligation) affords amide bonds under aqueous, acidic conditions without the need for protecting groups or coupling agents.
J. Bode
semanticscholar +1 more source
FEBS Open Bio, EarlyView.We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui +5 more
wiley +1 more source
CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation [PDF]
, 2003 CD40 is a 48-kDa phosphorylated transmembrane glycoprotein belonging to the TNF receptor superfamily. CD40 has been demonstrated on a range of cell types, and it has an important role in adaptive immunity and inflammation.
Callard, R.E. +4 more
core
Identification of a novel motif in DNA ligases exemplified by DNA ligase IV [PDF]
, 2006 DNA ligase IV is an essential protein that functions in DNA non-homologous end-joining, the major mechanism that rejoins DNA double-strand breaks in mammalian cells. LIG4 syndrome represents a human disorder caused by mutations in DNA ligase IV that lead
Doherty, Aidan J +5 more
core +1 more source
Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity.
Journal of the American Chemical Society, 2008 Described is a bioorthogonal reaction that proceeds with unusually fast reaction rates without need for catalysis: the cycloaddition of s-tetrazine and trans-cyclooctene derivatives.
Melissa L. Blackman, M. Royzen, J. Fox
semanticscholar +1 more source
Journal of Cardiothoracic Surgery, 2012 Introduction To date, most animal studies of myocardial ischemia have used open-chest models with direct surgical coronary artery ligation. We aimed to develop a novel, percutaneous, minimally-invasive, closed-chest model of experimental myocardial ...
Katsanos Konstantinos +8 more
doaj +1 more source
Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects
Advanced Functional Materials, EarlyView.Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu +6 more
wiley +1 more source
Replication-Coupled PCNA Unloading by the Elg1 Complex Occurs Genome-wide and Requires Okazaki Fragment Ligation [PDF]
, 2015 Open Access funded by Medical Research Council Acknowledgments We thank Dr Anja Bielinsky for plasmids and Dr. M.K. Raghuraman for a cdc9-1 strain. Alexander Lorenz (University of Aberdeen) provided valuable comments on the manuscript.
Donaldson, Anne Dunlop +4 more
core +2 more sources