Results 241 to 250 of about 427,156 (310)

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Comparison of Ligation of Intersphincteric Fistula Tract and Conventional Fistulectomy in the Management of Perianal Fistula. [PDF]

Cureus
Kumar D, Kawarat VC, Padmanabhan P, Ashok Kumar AK, Adalarasan S.   +4 more
europepmc   +1 more source

UCtracker: A Deep Learning–Based DNA Methylation Model for Noninvasive Diagnosis and Recurrence Surveillance of Urothelial Carcinoma in a Prospective Study

Advanced Science, EarlyView.
We developed UCtracker, a urine DNA methylation–based deep learning model, for noninvasive diagnosis and postoperative surveillance of urothelial carcinoma. UCtracker demonstrates high diagnostic accuracy, robustness at ultralow sequencing depth, early recurrence detection, and dynamic risk‐stratified monitoring of molecular residual disease ...
Shengwei Xiong, Gaojie Li, Yucai Wu, Yuan Liang, Heng Guo, Yu Zhang, Gengyan Xiong, Long Tian, Xin Zhang, Ye Tian, Zhengguo Ji, Bin Guo, Yue Shi, Jian Fan, Zhihua Li, Yanqing Gong, Shiming He, Xuesong Li, Weimin Ci, Liqun Zhou   +19 more
wiley   +1 more source

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

Surgical Strategy for Intractable Inguinal Lymphorrhea Using Combined Indocyanine Green Imaging and Negative Pressure Wound Therapy. [PDF]

Plast Reconstr Surg Glob Open
Tsutsumi A, Suzuki Y, Takayanagi R, Takada K, Kato T, Kishi K.   +5 more
europepmc   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Use of a Self-Irrigating Bipolar Sealer for Bilateral C2 Nerve Root Ligation During Atlantoaxial Instrumented Fusion. [PDF]

Cureus
Cho SS, Zhou JJ, Oppenlander ME, Coughlin DJ, Lee BS.   +4 more
europepmc   +1 more source

Ligation-assisted mucosal unroofing and snare resection: a simplified and cost-effective technique for gastric submucosal tumors. [PDF]

Endoscopy
Lu Q, Xie P, Liu Q, Guo S, Ye L, Wu J.
europepmc   +1 more source

Anchor clip-assisted detachable loop ligation for definitive hemostasis and closure of a high-risk bleeding gastric ulcer. [PDF]

Endoscopy
Sun Z, Li M, Shen P, Shi Q, Xu Y, Ma S.
europepmc   +1 more source

Metachronous Bilateral Ruptured True Deep Femoral Artery Aneurysms: A Case Report. [PDF]

Ann Vasc Dis
Suzuki T, Toya N, Murakami Y, Ohki T.
europepmc   +1 more source