Results 271 to 280 of about 497,237 (348)

Fermented Lacticaseibacillus Paracasei Cultures Ameliorate Colitis by Modulating Microbiota‐Derived Tryptophan Metabolism and Macrophage Polarization

Advanced Science, EarlyView.
A solid‐state fermented probiotic (PYW) is developed using wheat bran as substrate, containing high viable Lacticaseibacillus paracasei and bioactive metabolites. PYW alleviates intestinal inflammation by gut microbiota composition, enriching indole derivatives, activating aryl hydrocarbon receptor signaling, and regulating macrophage polarization. PYW
Heng Zhang, Jingzhou Sun, Xin Zheng, Huiqing Yang, Aowen Xie, Yuxuan Ding, Yuxia Mei, Jinshan Li, Yuanliang Hu, Min Ren, Yangyang Liu, Yunxiang Liang   +11 more
wiley   +1 more source

Mucosal Advancement Flap Versus Ligation of the Intersphincteric Fistula Tract for Transsphincteric Fistula-in-Ano: A Comparative Study in a Tertiary Care Hospital. [PDF]

Cureus
Reddy G S, Reddy R A.
europepmc   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, EarlyView.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

Rapid surgical intervention for acute spinal subdural hematoma triggered by ruptured spinal dural arteriovenous fistula: illustrative case. [PDF]

J Neurosurg Case Lessons
Naeem A, Mazza F, Shamisa A.
europepmc   +1 more source

Reprogramming the Myocardial Infarction Conductive Microenvironment with Superconductive Ionic Patch for Cardiac Function Repair

Advanced Science, EarlyView.
A super‐conductive ionic patch reprograms the post‐infarction microenvironment by enabling stable ionic migration and electrical signal transmission within damaged myocardium. The patch rapidly adheres to cardiac tissue, enhances conduction velocity, suppresses excitation‐contraction decoupling, and promotes structural and functional cardiac repair in ...
Changyong Wang, Zhuang Zhang, Qi Yin, Changgeng Xu, Linlin Liang, Siwei Li, Yuwei Zhao, Chunlan Wang, Jin Zhou   +8 more
wiley   +1 more source

Aluminum-[¹⁸F]fluoride radiolabeling of triarylphosphines for cell labeling via the perfluoroaryl azide Staudinger ligation. [PDF]

EJNMMI Radiopharm Chem
Biti A, Imlimthan S, Harjunpää H, Barakhtii D, Pöllänen T, Sukhova A, Wiedmer SK, Ekholm FS, Fagerholm S, Sarparanta M.   +9 more
europepmc   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

Efficient Assembly of Functional RNA by <i>in Situ</i> Phosphate Activation and Loop-Closing Ligation. [PDF]

J Am Chem Soc
Zhang J, Radakovic A, Bošković F, Aitken HRM, Wu LF, Szostak JW.   +5 more
europepmc   +1 more source

Sarcopenia modelling by portal vein ligation inducing hyperammonemia in rats. [PDF]

PLoS One
Nadinskaia M, Gulyaeva K, Sukhinin A, Sedova A, Boykova P, Izmailov I, Pokidova K, Kuzmin E, Venediktov A, Meglinski I, Piavchenko G.   +10 more
europepmc   +1 more source

Impaired nick recognition and ligation efficiency by LIG1 K845N variant linked to Huntington's disease. [PDF]

NAR Mol Med
Ratcliffe J, Lerner CE, Balu K, Chatterjee S, Lee KM, Caglayan M.   +5 more
europepmc   +1 more source