Results 141 to 150 of about 79,379 (295)
Advanced Science, EarlyView.Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu +11 more
wiley +1 more source
Morphological changes in major pelvic ganglion neurons and histological structure of bladder using rat model of partial urethral ligation [PDF]
, 1995 ラットの尿道狭窄モデルを作製し, ニューロンの形態学的変化, 膀胱の組織学的変化を観察し比較検討した。1)膀胱重量は1週間狭窄群は解除後ほぼ正常化したが, 4, 7, 11, 20週間狭窄群は解除後, 正常化しなかった。2) 1～4週間の尿道狭窄で, MPGニューロンの形態は狭窄解除6週間以内で可逆的であった。膀胱平滑筋/結合組織の比率(ADsc値)は狭窄後増大したが, 狭窄解除後は平滑筋の縮小, 線維成分の増加を認めた。3)狭窄期間が7週間以上におよぶと ...
高橋, 雅彦 +4 more
core
Advanced Science, EarlyView.A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu +7 more
wiley +1 more source
Advanced Science, EarlyView.This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu +10 more
wiley +1 more source
Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency
Advanced Science, EarlyView.How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen +10 more
wiley +1 more source
Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo
Advanced Science, EarlyView.As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao +12 more
wiley +1 more source
Grade IV hemorrhoidal disease represents the most advanced form of hemorrhoids and is frequently associated with severe prolapse, chronic inflammation, and a high risk of bleeding. Although minimally invasive techniques have gained popularity, excisional
Bahi, Achraf +3 more
core +1 more source
Blindness due to aneurysm of anterior communicating artery. With recovery following carotid ligation. [PDF]
British Journal of Ophthalmology, 1970 J H, Durston, B G, Parsons-Smith
openaire +2 more sources
Advanced Science, EarlyView.ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou +9 more
wiley +1 more source
Vaginal Stump Ligation for Cervical Cancer
Iranian Journal of Public Health, 2017 Background: We aimed to investigate the effect of vaginal stump ligation in laparoscopic cervical cancer surgery on the prevention of cancer cell detachment.
Yanling YANG +5 more
doaj