Results 191 to 200 of about 39,294 (296)

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Differentiating homicidal, suicidal, and autoerotic neck compression deaths. [PDF]

J Forensic Sci
Mullin SP, Hardiman R.
europepmc   +1 more source

ANIMAL LIGATURES. [PDF]

The Lancet, 1881
openaire   +1 more source

A Study of Fractures of Hyoid Bone and Thyroid Cartilage in Hanging and Ligature Strangulation

, 2015
Chandrakant M Kokatanur, Bheemappa Havanur, PK Devadass   +2 more
openalex   +1 more source

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

Injectable Thermosensitive Hydrogel Containing Bakuchiol Reduces Periodontal Inflammation and Alveolar Bone Loss in a Rat Model. [PDF]

J Funct Biomater
Shin SJ, Shim GY, Moon SH, Kim YJ, Kim HJ, Oh S, Lee JH, Bae JM.   +7 more
europepmc   +1 more source

LIGATURING FORCEPS. [PDF]

The Lancet, 1913
openaire   +1 more source

Diagnosis and treatment of anterior abdominal wall ligature fistulas

, 2016
A.G. Izmaylov, С. В. Доброквашин, D.E. Volkov, VYACHESLAV A. PYRKOV, Р Ф Закиров, S.A. Davlet-Kildeev   +5 more
openalex   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Therapeutic potential of exosomes in periodontal regeneration: Immunomodulatory and tissue-repair mechanisms. [PDF]

Front Immunol
Yang S, Han C, Wang Q, Ai Y, Wang D, Song W.   +5 more
europepmc   +1 more source