Results 221 to 230 of about 80,787 (394)

Tumor‐Associated Sympathetic Nerves Promote the Progression of Epstein‐Barr Virus‐Positive Diffuse Large B‐Cell Lymphoma

Advanced Science, EarlyView.
Sympathetic nerve innervation promotes the progression of Epstein‐Barr virus‐positive diffuse large B‐cell lymphoma (EBV+ DLBCL) via β2‐adrenergic receptors. The discovery of enhanced nerve infiltration and β2AR expression reveals a novel mechanism and highlights the sympathetic–β2AR axis as a promising target for therapeutic intervention in EBV+ DLBCL.
Silan Huang, Dexin Lei, Linbin Yang, Aiwei Bi, Yanlou Wang, Peng Zhang, Dongyu Zhuang, Honglian Liu, Qingqing Cai, Man Nie, Yi Xia   +10 more
wiley   +1 more source

Ligature-induced periodontitis in a transgenic mouse model of Alzheimer's disease dysregulates neuroinflammation, exacerbates cognitive impairment, and accelerates amyloid pathology. [PDF]

Brain Behav Immun Health
Jimenez-Harrison DM, Butler MJ, Ijaz H, Alsabbagh R, Bettes MN, DeMarsh JW, Mackey-Alfonso SE, Muscat SM, Alvarez BD, Blackwell JA, Taylor A, Jantsch J, Sanchez AA, Peters SB, Barrientos RM.   +14 more
europepmc   +1 more source

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

Establishing a Dual Murine Model to Explore the Interactions Between Diabetes and Periodontitis in Mice. [PDF]

Int J Mol Sci
Silva BR, Hidalgo MAR, Silva RCL, de Avila ED, Fuentes DLP, Carlos IZ, Figueiredo ID, Cerri ES, Cerri PS, Baviera AM, de Molon RS, Scarel-Caminaga RM.   +11 more
europepmc   +1 more source

piR‐RCC Suppresses Renal Cell Carcinoma Progression by Facilitating YBX‐1 Cytoplasm Localization

Advanced Science, EarlyView.
PIWI‐interacting RNAs (piRNAs), a novel category of small non‐coding RNAs, have been implicated in the development of various diseases. This study explores the tumor‐suppressive mechanism of a downregulated piRNA (designated piR‐RCC) in renal cell carcinoma (RCC), and provides a delivery strategy targeting RCC tumor by constructing a cell membrane ...
Ruyue Wang, Fan Li, Yudong Lin, Zeyi Lu, Wenqin Luo, Zhehao Xu, Ziwei Zhu, Yi Lu, Xudong Mao, Yang Li, Zhinian Shen, Haohua Lu, Yining Chen, Liqun Xia, Mingchao Wang, Lifeng Ding, Gonghui Li   +16 more
wiley   +1 more source

Evaluation of Apoptotic Caspase-3 Immunopositivity in Human Model of Asphyxial Death. [PDF]

Int J Mol Sci
Del Duca F, Treglia M, La Russa R, De Simone S, Cipolloni L, Maiese A, Frati P.   +6 more
europepmc   +1 more source

ANEURYSM OF THE ARTERIA INNOMINATA AND ORIGIN OF THE RIGHT SUBCLAVIAN ARTERY. LIGATURE OF COMMON CAROTID AND SUBCLAVIAN ARTERIES. [PDF]

S.W. Fearn
openalex   +1 more source

Orthodontic treatment of a transposed maxillary canine and first premolar in a young patient with class III malocclusion [PDF]

, 2015
Favero, Lorenzo, Gracco, ANTONIO LUIGI TIBERIO, Stellini, Edoardo   +2 more
core   +1 more source

RIG‐I‐Inducing Small Molecules Potently Inhibit HMA‐Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Advanced Science, EarlyView.
This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen, Jiaqi Wu, Yuntong Li, Jiayu Huang, Xiangqin Weng, Jiale Wu, Shujun Xiao, Huaxin Song, Zhengyuan Wang, Ni Yan, Fangfang Shi, Derun Zheng, Kai Tan, Hesong Zhang, Jingyi Cui, Wen Wu, Wei Wu, Sujiang Zhang, Min Lu   +18 more
wiley   +1 more source

NIR-responsive bio-system with sequential antibacterial and immunomodulatory effects for the treatment of periodontitis. [PDF]

Bioact Mater
Qiu X, Wang W, Shen C, Zhao Y, Song X, Yu Y, Liu C, Wu W, Miao L, Ren S.   +9 more
europepmc   +1 more source